Sugi Predict

Sugi Predict / Compounds / Desacetylvinblastinehydrazide

Desacetylvinblastinehydrazide

Desacetylvinblastinehydrazide

SCHEMBL29376353

CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(=O)NN)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1

nearest known ligand 0.90

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MLNR O43193 1/20 0.90
▸ PTGS2 P35354 1/20 0.90
▸ KCNH2 Q12809 1/20 0.90
▸ GHSR Q92847 1/20 0.90
▸ TUBB4A P04350 14/20 0.86
▸ TUBB P07437 14/20 0.86
▸ TUBA3C P0DPH7 14/20 0.86
▸ TUBA1B P68363 14/20 0.86
▸ TUBA4A P68366 14/20 0.86
▸ TUBB4B P68371 14/20 0.86
▸ TUBB3 Q13509 14/20 0.86
▸ TUBB2A Q13885 14/20 0.86
▸ TUBB8 Q3ZCM7 14/20 0.86
▸ TUBA3E Q6PEY2 14/20 0.86
▸ TUBA1A Q71U36 14/20 0.86
▸ TUBA1C Q9BQE3 14/20 0.86
▸ TUBB6 Q9BUF5 14/20 0.86
▸ TUBB2B Q9BVA1 14/20 0.86
▸ TUBB1 Q9H4B7 14/20 0.86
▸ MEN1 O00255 5/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Desacetylvinblastinehydrazide SCHEMBL15233643 1.00 MLNR (0.90) MLNRPTGS2KCNH2GHSRTUBB4A
Desacetylvinblastinehydrazide SCHEMBL29410063 1.00 MLNR (0.90) MLNRPTGS2KCNH2GHSRTUBB4A
Desacetylvinblastinehydrazide SCHEMBL17529277 1.00 MLNR (0.90) MLNRPTGS2KCNH2GHSRTUBB4A
Desacetylvinblastinehydrazide SCHEMBL13228849 1.00 MLNR (0.90) MLNRPTGS2KCNH2GHSRTUBB4A
Desacetylvinblastinehydrazide SCHEMBL15507828 1.00 MLNR (0.90) MLNRPTGS2KCNH2GHSRTUBB4A
SCHEMBL18602043 0.96 MLNR (0.91) MLNRPTGS2KCNH2GHSRTUBB4A
SCHEMBL18602221 0.96 MLNR (0.91) MLNRPTGS2KCNH2GHSRTUBB4A
SCHEMBL18602222 0.96 MLNR (0.90) MLNRPTGS2KCNH2GHSRTUBB4A
SCHEMBL19443227 0.96 MLNR (0.90) MLNRPTGS2KCNH2GHSRTUBB4A
SCHEMBL19787808 0.96 MLNR (0.90) MLNRPTGS2KCNH2GHSRTUBB4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4703389-A1 ANTI-PTK7 ANTIBODY AND USES THEREOF MabCare Therapeutics (CN) 2026-03-04 — — EP claimed
US-20250381202-A1 PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY ZOUNEK ALEX (DE) 2025-12-18 — — US claimed
EP-4551565-A1 PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY Zounek, Alex (DE) 2025-05-14 — — EP claimed
WO-2025039809-A1 ANTI-ROR1 ANTIBODY AND USE THEREOF 上海麦科思生物医药有限公司 2025-02-27 — — WO claimed
WO-2024222384-A1 ANTI-PTK7 ANTIBODY AND USES THEREOF 上海麦科思生物医药有限公司 2024-10-31 — — WO claimed
CN-118852442-A Anti-PTK 7 antibodies and uses thereof 上海麦科思生物医药有限公司 2024-10-29 — — CN claimed
US-20240024494-A1 SMALL-MOLECULE CONJUGATE AND USE THEREOF ANHUI CHINA RESOURCES JINCHAN PHARMACEUTICAL CO., LTD. (CN) 2024-01-25 — — US claimed
WO-2024008833-A1 PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY ZOUNEK ALEX (DE) 2024-01-11 — — WO claimed
CN-113633780-B Small molecule conjugate and application thereof 上海邈基生物科技有限公司 2023-08-29 — — CN claimed
CN-114230561-A MDM2 inhibitor micromolecule compound and application thereof 中国人民解放军海军军医大学 2022-03-25 — — CN claimed
WO-2022052823-A1 SMALL-MOLECULE CONJUGATE AND USE THEREOF 上海邈基生物科技有限公司 2022-03-17 — — WO claimed
US-12611461-B2 Bioorthogonal compositions TAMBO, INC. (US) 2026-04-28 — — US disclosed
US-12589162-B2 Trans-cyclooctene prodrug of monomethyl auristatin E TAMBO, INC. (US) 2026-03-31 — — US disclosed
EP-4713022-A1 TRANS-CYCLOOCTENE-MODIFIED TARGETED PROTEIN DEGRADER CONJUGATES Tambo, Inc. (US) 2026-03-25 — — EP disclosed
EP-4704904-A1 TETRAZINE-BASED TARGETING AGENTS FOR IN VIVO DELIVERY OF A PAYLOAD Tambo, Inc. (US) 2026-03-11 — — EP disclosed
CN-114230561-A MDM2 inhibitor micromolecule compound and application thereof 中国人民解放军海军军医大学 2022-03-25 — — CN disclosed
EP-3971227-A1 POLYMER, METHOD FOR PRODUCING POLYMER, AND DRUG CONJUGATE Kawasaki Institute of Industrial Promotion (JP) 2022-03-23 — — EP disclosed
WO-2022052823-A1 SMALL-MOLECULE CONJUGATE AND USE THEREOF 上海邈基生物科技有限公司 2022-03-17 — — WO disclosed
US-11253600-B2 Bioorthogonal compositions TAMBO, INC. (US) 2022-02-22 — — US disclosed
WO-2022032191-A1 TRANS-CYCLOOCTENE BIOORTHOGONAL AGENTS AND USES IN CANCER AND IMMUNOTHERAPY TAMBO, INC. (US) 2022-02-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250381202-A1 PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY KIT, CTSL, PAICS MLNR 1582/4885PTGS2 3788/4885KCNH2 4170/4885
US-12589162-B2 Trans-cyclooctene prodrug of monomethyl auristatin E AURKC, AURKA, QPCT MLNR 2008/4885PTGS2 3767/4885KCNH2 4431/4885
US-20240024494-A1 SMALL-MOLECULE CONJUGATE AND USE THEREOF SLC7A5, SLC43A1, CD44 MLNR 1612/4885PTGS2 3690/4885KCNH2 4219/4885
US-12611461-B2 Bioorthogonal compositions ACVRL1, FCGR2A, CHIT1 MLNR 2663/4885PTGS2 2780/4885KCNH2 1983/4885
US-11253600-B2 Bioorthogonal compositions TIE1, BBOX1, ST14 MLNR 3591/4885PTGS2 570/4885KCNH2 4651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.