Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 10/20 | 0.60 |
| ▸ | DRD2 | P14416 | 8/20 | 0.60 |
| ▸ | DRD3 | P35462 | 8/20 | 0.60 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9393661 | 0.93 | DRD4 (0.67) | DRD4DRD2DRD3HRH4KMT2A | |
| Oxalic Acid SCHEMBL9391376 | 0.86 | DRD3 (0.60) | DRD4DRD2DRD3HRH4HTR1A | |
| SCHEMBL8682915 | 0.85 | HRH4 (0.69) | DRD4DRD2DRD3HRH4HTR1A | |
| SCHEMBL30041328 | 0.85 | HRH4 (0.69) | DRD4DRD2DRD3HRH4HTR1A | |
| SCHEMBL8874997 | 0.79 | DRD4 (0.57) | DRD4DRD2DRD3HTR7HTR1A | |
| SCHEMBL23964200 | 0.78 | HRH4 (0.63) | DRD4DRD2DRD3HRH4HTR1A | |
| SCHEMBL30041451 | 0.78 | HRH4 (0.63) | DRD4DRD2DRD3HRH4HTR1A | |
| SCHEMBL25183371 | 0.78 | HRH4 (0.66) | DRD4DRD2DRD3HRH4MAPT | |
| SCHEMBL9392986 | 0.78 | DRD2 (0.67) | DRD4DRD2DRD3HRH4MEN1 | |
| SCHEMBL8681808 | 0.77 | HRH4 (0.73) | DRD4DRD2DRD3HRH4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994024105-A1 | INDOLE DERIVATIVES AS DOPAMINE D4 ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |