Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 9/20 | 0.57 |
| ▸ | DRD3 | P35462 | 5/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8875085 | 0.90 | DRD4 (0.53) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL8873619 | 0.85 | DRD4 (0.58) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL9393661 | 0.83 | DRD4 (0.67) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| Oxalic Acid SCHEMBL9396183 | 0.79 | DRD4 (0.60) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL8431224 | 0.76 | MAOA (0.67) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL5198717 | 0.73 | DRD2 (1.00) | DRD4DRD3DRD2KDM4EMAPT | |
| SCHEMBL24851793 | 0.72 | IL4I1 (0.54) | KDM4EALDH1A1PARP1KCNH2PARP2 | |
| SCHEMBL8071284 | 0.72 | PARP1 (0.71) | DRD4DRD2KMT2APARP1KCNH2 | |
| SCHEMBL8687797 | 0.72 | DRD4 (1.00) | DRD4DRD2KDM4EALDH1A1GAA | |
| SCHEMBL8874381 | 0.72 | KDM4E (0.52) | DRD4DRD3DRD2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607946-A | Quinolone derivatives as dopamine D4 ligands | MERCK SHARP & DOHME LTD. (GB) | 1997-03-04 | — | — | US | disclosed |