SCHEMBL9397249

SCHEMBL9397249

COc1ccc(CCN2CCCNCC2)cc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 3/20 0.74
SIGMAR1 Q99720 4/20 0.69
MAOA P21397 1/20 0.54
MAOB P27338 1/20 0.54
SLC6A4 P31645 2/20 0.53
KCNJ1 P48048 1/20 0.53
KCNH2 Q12809 1/20 0.53
SLC6A2 P23975 1/20 0.53
SLC6A3 Q01959 1/20 0.53
SMPD1 P17405 1/20 0.51
MEN1 O00255 1/20 0.50
CHRM2 P08172 1/20 0.50
CHRM1 P11229 1/20 0.50
ADRA2C P18825 1/20 0.50
CCR2 P41597 1/20 0.50
CXCL12 P48061 1/20 0.50
BLM P54132 1/20 0.50
CXCR4 P61073 1/20 0.50
KMT2A Q03164 1/20 0.50
TDP1 Q9NUW8 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28504266 0.99 HRH3 (0.72) HRH3SIGMAR1MAOAMAOBSLC6A4
SCHEMBL9320418 0.94 SIGMAR1 (0.77) HRH3SIGMAR1MAOAMAOBSLC6A4
Hydrochloric Acid SCHEMBL14486598 0.92 SIGMAR1 (0.75) HRH3SIGMAR1MAOAMAOBSLC6A4
SCHEMBL29356024 0.86 HRH3 (1.00) HRH3SIGMAR1MAOAMAOBSLC6A4
SCHEMBL9397176 0.85 CXCR4 (0.71) HRH3SIGMAR1MEN1CHRM2CHRM1
SCHEMBL11156977 0.84 HRH3 (0.96) HRH3SIGMAR1MAOAMAOBSLC6A4
SCHEMBL22254774 0.83 HRH3 (0.72) HRH3SIGMAR1SLC6A4KCNJ1KCNH2
SCHEMBL29283196 0.82 SIGMAR1 (0.59) HRH3SIGMAR1
SCHEMBL8828170 0.82 SIGMAR1 (0.61) SIGMAR1SLC6A4SMPD1
SCHEMBL5752571 0.80 KCNH2 (0.64) HRH3SIGMAR1MAOASLC6A4KCNJ1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107304204-B Method for preparing N-heterocyclic compound 广东东阳光药业有限公司 2020-12-22 CN disclosed
US-5340811-A Bronchodilator agent ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1994-08-23 US disclosed
EP-0471841-A1 SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1992-02-26 EP disclosed