Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8601956 | 0.90 | GAK (0.42) | GAKTLR8GAAMAPTATM | |
| SCHEMBL9397293 | 0.81 | SLC22A12 (0.45) | GAKERN1CYP1A2 | |
| SCHEMBL599975 | 0.75 | PARP1 (0.44) | GAKMAPTERN1PARP1CCNC | |
| SCHEMBL18544879 | 0.71 | GAK (0.44) | GAKGAAMAPTATMPARP1 | |
| SCHEMBL28164080 | 0.71 | TLR8 (0.54) | TLR8GAAMAPTATMNR4A2 | |
| SCHEMBL29509132 | 0.71 | TLR8 (0.54) | TLR8GAAMAPTATMNR4A2 | |
| Iodide SCHEMBL11565912 | 0.70 | GAK (0.43) | GAKGAAMAPTATMPARP1 | |
| SCHEMBL10316081 | 0.69 | GAK (0.43) | GAKPARP1CCNCCDK8CYP1A2 | |
| SCHEMBL1490718 | 0.68 | ALK (0.50) | GAKTLR8ERN1CYP1A2 | |
| SCHEMBL3319590 | 0.68 | NR4A2 (0.61) | GAKMAPTPARP1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5344922-A | 4-hydroxyquinaldic acid derivatives | BOARD OF REGENTS, UNIVERSITY OF TEXAS | 1994-09-06 | — | — | US | disclosed |
| US-5028707-A | 4-hydroxyquinaldic acid derivatives | BOARD OF REGENTS, UNIVERSITY OF TEXAS (US) | 1991-07-02 | — | — | US | disclosed |
| WO-1991007390-A1 | 4-HYDROXYQUINALDIC ACID DERIVATIVES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1991-05-30 | — | — | WO | disclosed |