Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1490718 | 0.90 | ALK (0.50) | SLC22A12ALKCYP1A2CYP2C19HTT | |
| SCHEMBL9397259 | 0.81 | GAK (0.37) | CYP1A2GAKERN1 | |
| SCHEMBL360254 | 0.75 | SLC22A12 (0.51) | SLC22A12ALKCYP1A2CYP2C19HTT | |
| SCHEMBL23498024 | 0.73 | SLC22A12 (0.37) | SLC22A12ALKCYP2C19GAKKDM4E | |
| SCHEMBL4470963 | 0.71 | ALK (0.53) | SLC22A12ALKCYP1A2CYP2C19HTT | |
| SCHEMBL28164080 | 0.71 | TLR8 (0.54) | HTTKDM4EALDH1A1SMN1; SMN2EGFR | |
| SCHEMBL29509132 | 0.71 | TLR8 (0.54) | HTTKDM4EALDH1A1SMN1; SMN2EGFR | |
| SCHEMBL29896720 | 0.71 | ALK (0.53) | SLC22A12ALKCYP1A2CYP2C19HTT | |
| SCHEMBL30135541 | 0.70 | SLC22A12 (0.50) | SLC22A12ALKKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7374970 | 0.70 | SLC22A12 (0.50) | SLC22A12ALKKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5344922-A | 4-hydroxyquinaldic acid derivatives | BOARD OF REGENTS, UNIVERSITY OF TEXAS | 1994-09-06 | — | — | US | disclosed |
| US-5028707-A | 4-hydroxyquinaldic acid derivatives | BOARD OF REGENTS, UNIVERSITY OF TEXAS (US) | 1991-07-02 | — | — | US | disclosed |
| WO-1991007390-A1 | 4-HYDROXYQUINALDIC ACID DERIVATIVES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1991-05-30 | — | — | WO | disclosed |