Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.30 |
| ▸ | DGKA | P23743 | 1/20 | 0.30 |
| ▸ | BCL9 | O00512 | 1/20 | 0.30 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.30 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9398201 | 0.83 | ALDH1A1 (0.36) | ALDH1A1FFAR3TSHRNAAA | |
| SCHEMBL31534023 | 0.80 | ALDH1A1 (0.58) | ALDH1A1CES2CES1HDAC3HDAC1 | |
| SCHEMBL20962970 | 0.80 | ALDH1A1 (0.58) | ALDH1A1CES2CES1HDAC3HDAC1 | |
| SCHEMBL8116737 | 0.77 | ALDH1A1 (0.44) | ALDH1A1 | |
| SCHEMBL30568759 | 0.77 | ALDH1A1 (1.00) | ALDH1A1CES2CES1HDAC3HDAC1 | |
| SCHEMBL8158 | 0.77 | ALDH1A1 (1.00) | ALDH1A1CES2CES1HDAC3HDAC1 | |
| SCHEMBL9556715 | 0.75 | ALDH1A1 (0.94) | ALDH1A1CES2CES1HDAC3HDAC1 | |
| SCHEMBL10640242 | 0.75 | ALDH1A1 (0.94) | ALDH1A1CES2CES1HDAC3HDAC1 | |
| SCHEMBL17477083 | 0.75 | ALDH1A1 (0.94) | ALDH1A1CES2CES1HDAC3HDAC1 | |
| SCHEMBL27743311 | 0.75 | ALDH1A1 (0.94) | ALDH1A1CES2CES1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354887-A | Reacting carbon monoxide and water with diacryloxylated butene in polar, aprotic solvent and catalyst | RHONE-POULENC CHIMIE (FR) | 1994-10-11 | — | — | US | disclosed |
| EP-0395545-B1 | PROCESS FOR PREPARING 1,6-HEXENEDIOIC ACIDS | RHONE-POULENC CHIMIE (FR) | 1993-07-28 | — | — | EP | disclosed |
| EP-0433189-B1 | PROCESS FOR THE PREPARATION OF DIESTERS OF HEXENEDIOIC ACID | RHONE-POULENC CHIMIE (FR) | 1993-06-23 | — | — | EP | disclosed |
| EP-0433190-B1 | PROCESS FOR PREPARING 1,6-HEXENDIOIC ACIDS | RHONE-POULENC CHIMIE (FR) | 1993-04-21 | — | — | EP | disclosed |
| EP-0347340-B1 | PROCESS FOR THE PREPARATION OF DIESTERS OF HEXENEDIOIC ACID | RHONE-POULENC CHIMIE (FR) | 1992-04-08 | — | — | EP | disclosed |
| US-5087735-A | Reacting carbon monoxide, alcohol and diacyloxylated butene in polar, aprotic solvent and catalyst system | RHONE-POULENC CHIMIE (FR) | 1992-02-11 | — | — | US | disclosed |
| US-5077433-A | Reacing carbon monoxide, water and diacyloxylated butene in th e presence of palladium and quaternary onium chloride | RHONE-POULENC CHIMIE (FR) | 1991-12-31 | — | — | US | disclosed |
| EP-0433190-A1 | Process for preparing 1,6-hexendioic acids | RHONE-POULENC CHIMIE (FR) | 1991-06-19 | — | — | EP | disclosed |
| EP-0433189-A1 | Process for the preparation of diesters of hexenedioic acid | RHONE-POULENC CHIMIE (FR) | 1991-06-19 | — | — | EP | disclosed |
| EP-0395545-A2 | Process for preparing 1,6-hexenedioic acids | RHONE-POULENC CHIMIE (FR) | 1990-10-31 | — | — | EP | disclosed |
| US-4925973-A | REACTION OF DIACETOXY BUTENE WITH ALCOHOL AND CARBON MONOXIDE | RHONE-POULENC CHIMIE (FR) | 1990-05-15 | — | — | US | disclosed |
| EP-0347340-A1 | Process for the preparation of diesters of hexenedioic acid | RHONE-POULENC CHIMIE (FR) | 1989-12-20 | — | — | EP | disclosed |