Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 18/20 | 0.64 |
| ▸ | ALDH1A3 | P47895 | 15/20 | 0.64 |
| ▸ | ALDH1A2 | O94788 | 14/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19747395 | 0.88 | ALDH1A1 (0.62) | ALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL21271734 | 0.88 | ALDH1A1 (0.62) | ALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL19747379 | 0.84 | ALDH1A1 (0.58) | ALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL21291492 | 0.82 | ALDH1A1 (0.55) | ALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL19746635 | 0.81 | ALDH1A1 (0.59) | ALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL15865180 | 0.79 | ALDH1A1 (0.60) | ALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL15865177 | 0.79 | ALDH1A1 (0.60) | ALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL19745999 | 0.78 | ALDH1A1 (1.00) | ALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL21271707 | 0.77 | ALDH1A1 (0.56) | ALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL8242227 | 0.77 | NPC1 (0.70) | ALDH1A1SMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021541-A1 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION | 2011-01-27 | — | — | US | disclosed |
| US-20110021541-A1 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION | 2011-01-27 | — | — | US | disclosed |
| US-20110021541-A1 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION | 2011-01-27 | — | — | US | disclosed |
| WO-2009064802-A2 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ELI LILLY & CO. (US) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021541-A1 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | PIK3CD, PI4KB, PI4KA | ALDH1A1 4614/4885ALDH1A3 4557/4885ALDH1A2 4527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.