SCHEMBL9399738

SCHEMBL9399738

O=C(O)c1ccc[nH]1.c1ccn2cncc2c1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.36
TDO2 P48775 1/20 0.36
TBXAS1 P24557 3/20 0.36
TSHR P16473 1/20 0.36
BRAF P15056 1/20 0.35
CYP2D6 P10635 2/20 0.34
PTGS1 P23219 1/20 0.34
PTGS2 P35354 1/20 0.34
CYP1A2 P05177 1/20 0.34
GAA P10253 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
ALDH1A1 P00352 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
SIRT2 Q8IXJ6 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL65171 0.76
SCHEMBL2121805 0.76
SCHEMBL28486243 0.75 ALOX15 (0.48) IDO1TDO2TBXAS1RAB9ASMN1; SMN2
SCHEMBL29974816 0.75 ALOX15 (0.48) IDO1TDO2TBXAS1RAB9ASMN1; SMN2
SCHEMBL28298 0.73
SCHEMBL10141203 0.73
SCHEMBL21114388 0.73 TSHR (0.57) TSHRCYP2D6CYP1A2GAARAB9A
SCHEMBL10141202 0.73
Iodomethane SCHEMBL11535813 0.71 ALOX15 (0.44) IDO1TDO2TBXAS1GAARAB9A
Water SCHEMBL5567597 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5331006-A Cholecystokinin, antisecretory agents WARNER-LAMBERT COMPANY (US) 1994-07-19 US disclosed