Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9400066 | 0.91 | PDE7A (0.55) | PDE7AALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL19563634 | 0.82 | ALDH1A1 (0.64) | ALDH1A1LMNAMAPTSMN1; SMN2HPGD | |
| SCHEMBL2961786 | 0.82 | PDE7A (0.74) | PDE7AALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL9274565 | 0.82 | PDE7A (0.57) | PDE7AALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3839379 | 0.81 | PDE7A (0.53) | PDE7AALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL19563670 | 0.79 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTSMN1; SMN2HPGD | |
| SCHEMBL3838372 | 0.79 | ALDH1A1 (0.67) | ALDH1A1LMNAMAPTSMN1; SMN2HPGD | |
| SCHEMBL10387432 | 0.78 | PDE7A (0.71) | PDE7AALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL11743249 | 0.78 | CYP19A1 (0.51) | PDE7AALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL11743270 | 0.78 | CYP19A1 (0.51) | PDE7AALDH1A1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281590-A | Administering oxazepine derivative for treatment of osteoporosis | G. D. SEARLE & CO. (US) | 1994-01-25 | — | — | US | disclosed |
| US-5180720-A | Prostaglandin E2 antagonists | G. D. SEARLE & CO. (US) | 1993-01-19 | — | — | US | disclosed |