Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.35 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL9400377 | 0.98 | NR1H4 (0.36) | NR1H4MAPTTP53MEN1KMT2A | |
| Diethylamine SCHEMBL9400395 | 0.96 | NR1H4 (0.38) | NR1H4MAPTTP53MEN1KMT2A | |
| Diethylamine SCHEMBL9400374 | 0.94 | NR1H4 (0.37) | NR1H4MAPTTP53MEN1KMT2A | |
| Diethylamine SCHEMBL9400354 | 0.92 | NR1H4 (0.40) | NR1H4MEN1KMT2ANPC1ALDH1A1 | |
| Diethylamine SCHEMBL9400356 | 0.91 | NR1H4 (0.36) | NR1H4MAPTTP53MEN1KMT2A | |
| SCHEMBL9400443 | 0.91 | MAPT (0.38) | MAPTTP53KMT2ANPC1RXFP1 | |
| Diethylamine SCHEMBL9400365 | 0.90 | NR1H4 (0.39) | NR1H4MAPTTP53MEN1KMT2A | |
| SCHEMBL9400372 | 0.89 | MAPT (0.38) | MAPTTP53KMT2ANPC1RXFP1 | |
| Diethylamine SCHEMBL9400493 | 0.89 | CHRNB2 (0.40) | NR1H4MAPTTP53MEN1KMT2A | |
| SCHEMBL9400392 | 0.87 | MAPT (0.37) | NR1H4MAPTTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5372917-A | Excellent color forming property, storage stability and recorded image preservability; pyrazolone derivatives | KANZAKI PAPER MANUFACTURING CO., LTD. (JP) | 1994-12-13 | — | — | US | disclosed |