Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Mannitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.46 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL27352819 | 0.93 | USP2 (0.60) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Mannitol SCHEMBL1287879 | 0.93 | USP2 (0.60) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Adonitol SCHEMBL27529790 | 0.88 | USP2 (0.54) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Glycerin SCHEMBL450871 | 0.88 | OR51E2 (0.59) | USP2SLCO1B1PDE4ALMNAOR51E2 | |
| Glycerin SCHEMBL4743691 | 0.88 | OR51E2 (0.59) | USP2SLCO1B1PDE4ALMNAOR51E2 | |
| Gluconic Acid SCHEMBL5805996 | 0.83 | PDE4A (0.79) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Gluconic Acid SCHEMBL28069153 | 0.83 | PDE4A (0.79) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Glycerin SCHEMBL8821885 | 0.81 | OR51E2 (0.50) | LMNATDP1OR51E2GLRA1SLC6A9 | |
| Gluconic Acid SCHEMBL1070308 | 0.81 | PDE4A (0.76) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Gluconic Acid SCHEMBL17965938 | 0.81 | PDE4A (0.76) | USP2SLCO1B1PDE4ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374551-A | Measurement of metabolism of alpha-methyl glucoside | BIOLOG, INC. (US) | 1994-12-20 | — | — | US | disclosed |