Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.61 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16301440 | 0.89 | KIF11 (0.60) | MAPKAPK2LMNAMAPTTP53KIF11 | |
| SCHEMBL2707877 | 0.83 | MAPKAPK2 (0.62) | MAPKAPK2MAPTTP53 | |
| SCHEMBL8403023 | 0.81 | TP53 (0.60) | MAPKAPK2LMNAMAPTTP53KIF11 | |
| SCHEMBL8402845 | 0.81 | KIF11 (0.59) | LMNAMAPTTP53KIF11 | |
| SCHEMBL945721 | 0.81 | MAPKAPK2 (0.56) | MAPKAPK2BCHEACHES1PR1LMNA | |
| SCHEMBL6244101 | 0.79 | MAPKAPK2 (0.60) | MAPKAPK2BCHEACHES1PR1LMNA | |
| SCHEMBL6238198 | 0.79 | MAPKAPK2 (0.63) | MAPKAPK2BCHEACHES1PR1LMNA | |
| SCHEMBL9401163 | 0.78 | LMNA (0.70) | BCHEACHELMNAMAPTKIF11 | |
| SCHEMBL8403014 | 0.78 | TP53 (0.63) | MAPKAPK2LMNAMAPTTP53KIF11 | |
| SCHEMBL16302690 | 0.77 | LMNA (0.59) | MAPKAPK2LMNAMAPTTP53KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314908-A | Compounds useful as antiproliferative agents | WHITBY RESEARCH, INC. (US) | 1994-05-24 | — | — | US | disclosed |
| EP-0549916-A2 | Compounds useful as antiproliferative agents | WHITBY RESEARCH, Inc. (US) | 1993-07-07 | — | — | EP | disclosed |
| US-5206377-A | Compounds useful as antiproliferative agents | WHITBY RESEARCH, INC. (US) | 1993-04-27 | — | — | US | disclosed |