SCHEMBL9401212

SCHEMBL9401212

COc1cc(OC)nc(SC(C=O)c2ccc([N+](=O)[O-])cc2)n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGES O14684 1/20 0.39
ALOX5 P09917 1/20 0.39
MAPT P10636 3/20 0.39
LMNA P02545 1/20 0.39
PTGS2 P35354 3/20 0.37
PTGS1 P23219 1/20 0.37
TDP1 Q9NUW8 2/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
TSHR P16473 1/20 0.37
MAPK1 P28482 1/20 0.37
PHLPP2 Q6ZVD8 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
CYP19A1 P11511 2/20 0.36
KMT2A Q03164 3/20 0.35
MEN1 O00255 2/20 0.35
PDGFRB P09619 1/20 0.35
PDGFRA P16234 1/20 0.35
POLB P06746 1/20 0.35
PABPC1 P11940 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9572237 0.83 EDNRB (0.36) PTGESALOX5LMNACYP1A2CYP3A4
SCHEMBL9401337 0.82 EDNRB (0.38) LMNACYP1A2L3MBTL1KMT2AMEN1
SCHEMBL9401354 0.82 GAA (0.39) CYP1A2L3MBTL1HTTSMN1; SMN2GAA
SCHEMBL9401376 0.82 L3MBTL1 (0.34) MAPTLMNACYP1A2L3MBTL1HTT
SCHEMBL9401440 0.81 PTGES (0.40) PTGESALOX5MAPTKMT2A
SCHEMBL9401343 0.80 TP53 (0.33) CYP1A2TSHR
SCHEMBL9401467 0.79 PTGES (0.37) PTGESALOX5MAPTLMNAPTGS2
SCHEMBL9401586 0.79 PTGES (0.39) PTGESALOX5
SCHEMBL9401309 0.79 PTGES (0.39) PTGESALOX5CYP19A1HTTKDM4E
SCHEMBL9401347 0.77 MEN1 (0.39) CYP1A2CYP3A4KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5346880-A Pre- and postemergence NIHON BAYER AGROCHEM K.K. (JP) 1994-09-13 US disclosed
EP-0565951-A1 Herbicidally active pyrimidinylthioalkane derivatives NIHON BAYER AGROCHEM K.K. (JP) 1993-10-20 EP disclosed