Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | MIF | P14174 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9402446 | 1.00 | MAPT (0.61) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5604228 | 0.75 | ALDH1A1 (0.76) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5605289 | 0.75 | ALDH1A1 (0.76) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5604224 | 0.75 | ALDH1A1 (0.76) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7328464 | 0.74 | ALDH1A1 (0.49) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7328466 | 0.74 | ALDH1A1 (0.49) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9740855 | 0.74 | ALDH1A1 (0.49) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8171751 | 0.73 | MAPT (0.61) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8171749 | 0.72 | KDM4E (0.59) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL28138472 | 0.71 | KDM4E (0.62) | MAPTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5334606-A | Analgesics, antiinflammatory agents | MERCK SHARPE & DOHME LTD. (GB) | 1994-08-02 | — | — | US | disclosed |
| EP-0545478-A1 | Heterocyclic compounds as tachykinin antagonists | MERCK SHARP & DOHME LTD. (GB) | 1993-06-09 | — | — | EP | disclosed |