Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740855 | 1.00 | ALDH1A1 (0.49) | ALDH1A1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL7328466 | 1.00 | ALDH1A1 (0.49) | ALDH1A1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL7273033 | 0.86 | ALDH1A1 (0.51) | ALDH1A1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL9046126 | 0.77 | IKBKB (0.58) | ALDH1A1MAPTACHENPC1RAB9A | |
| SCHEMBL9047619 | 0.77 | KDM4E (0.51) | ALDH1A1MAPTSMN1; SMN2ACHEKMT2A | |
| SCHEMBL9047611 | 0.77 | KDM4E (0.51) | ALDH1A1MAPTSMN1; SMN2ACHEKMT2A | |
| SCHEMBL9047790 | 0.77 | DYRK2 (0.56) | ALDH1A1MAPTHTTNPSR1ACHE | |
| SCHEMBL9047786 | 0.77 | DYRK2 (0.56) | ALDH1A1MAPTHTTNPSR1ACHE | |
| SCHEMBL9046118 | 0.77 | IKBKB (0.58) | ALDH1A1MAPTACHENPC1RAB9A | |
| SCHEMBL7170445 | 0.76 | ALDH1A1 (0.66) | ALDH1A1MAPTHTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0396065-A1 | Novel amino acid derivatives possessing renin-inhibitory activities | Japan Tobacco Inc. (JP) | 1990-11-07 | — | — | EP | disclosed |
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| US-4857650-A | Novel renin inhibitory amino acid derivatives | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| US-4853463-A | Amino acid derivatives | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-08-01 | — | — | US | disclosed |
| US-4841067-A | RENIN INHIBITORS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-06-20 | — | — | US | disclosed |
| US-4711958-A | HYPOTENSIVE AGENTS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1987-12-08 | — | — | US | disclosed |
| EP-0244083-A2 | Amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1987-11-04 | — | — | EP | disclosed |
| US-4656269-A | RENIN INHIBITORY EFFECT WHEN ADMINISTERING ORALLY; HYPOTENSIVE AGENTS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1987-04-07 | — | — | US | disclosed |
| EP-0216539-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1987-04-01 | — | — | EP | disclosed |
| EP-0206807-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-12-30 | — | — | EP | disclosed |
| EP-0200406-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-11-05 | — | — | EP | disclosed |
| EP-0190891-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-08-13 | — | — | EP | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |