Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 5/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9402789 | 0.92 | PTPN11 (0.47) | PTPN11PLA2G2ABLMPTPN1PTPN6 | |
| SCHEMBL9402646 | 0.91 | PTPN11 (0.50) | PTPN11PLA2G2ABLMMAOBPLA2G4B | |
| SCHEMBL9402877 | 0.91 | PTPN11 (0.50) | PTPN11PLA2G2ABLMMAOBPLA2G4B | |
| SCHEMBL9402542 | 0.91 | PTPN11 (0.50) | PTPN11PLA2G2ABLMMAOBPLA2G4B | |
| SCHEMBL9403014 | 0.90 | PTPN11 (0.46) | PTPN11PLA2G2ABLMPTPN1PTPN6 | |
| SCHEMBL9402533 | 0.87 | PLA2G2A (0.52) | PTPN11PLA2G2ABLMPTPN1PTPN6 | |
| SCHEMBL9402707 | 0.87 | PLA2G2A (0.52) | PTPN11PLA2G2ABLMPTPN1PTPN6 | |
| SCHEMBL9402594 | 0.87 | CYSLTR2 (0.46) | PTPN11PLA2G2ABLMMAOBPTPN1 | |
| SCHEMBL9402565 | 0.86 | PTPN11 (0.47) | PTPN11PLA2G2ABLMPTPN1PTPN6 | |
| SCHEMBL9403064 | 0.85 | PTPN11 (0.48) | PTPN11PLA2G2ABLMPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5298652-A | N-substituted glycines, inhibitors of phospholipase A2 | HOFFMANN-LA ROCHE INC. (US) | 1994-03-29 | — | — | US | disclosed |