Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 3/20 | 0.61 |
| ▸ | PLA2G4B | P0C869 | 4/20 | 0.60 |
| ▸ | THRA | P10827 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.55 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9402724 | 1.00 | SMPD1 (0.61) | SMPD1PLA2G4BTHRATHRBKMT2A | |
| SCHEMBL9402624 | 1.00 | SMPD1 (0.61) | SMPD1PLA2G4BTHRATHRBKMT2A | |
| SCHEMBL9402703 | 0.88 | SMPD1 (0.58) | SMPD1PLA2G4BTHRATHRBKMT2A | |
| SCHEMBL9402627 | 0.88 | SMPD1 (0.62) | SMPD1PLA2G4BTHRATHRBKMT2A | |
| SCHEMBL9402734 | 0.88 | SMPD1 (0.62) | SMPD1PLA2G4BTHRATHRBKMT2A | |
| SCHEMBL9402521 | 0.88 | PLA2G2A (0.57) | SMPD1PLA2G4BTHRATHRBPLA2G2A | |
| SCHEMBL9402732 | 0.88 | SMPD1 (0.62) | SMPD1PLA2G4BTHRATHRBKMT2A | |
| SCHEMBL9402540 | 0.87 | PLA2G2A (0.66) | SMPD1PLA2G4BTHRATHRBPLA2G2A | |
| SCHEMBL9402602 | 0.87 | PLA2G2A (0.66) | SMPD1PLA2G4BTHRATHRBPLA2G2A | |
| SCHEMBL9402653 | 0.86 | TSHR (0.60) | SMPD1PLA2G4BTHRATHRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5298652-A | N-substituted glycines, inhibitors of phospholipase A2 | HOFFMANN-LA ROCHE INC. (US) | 1994-03-29 | — | — | US | disclosed |