Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1562761 | 0.78 | IDO1 (0.47) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL31574390 | 0.78 | IDO1 (0.47) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL5749089 | 0.78 | ALDH1A1 (0.59) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL30900875 | 0.78 | ALDH1A1 (0.59) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL9770091 | 0.78 | GABRA1 (0.48) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL4659373 | 0.75 | ALDH1A1 (0.44) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL9404195 | 0.75 | PARP1 (0.43) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL1892202 | 0.74 | ALDH1A1 (0.67) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL5747969 | 0.73 | MEN1 (0.38) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL5748791 | 0.73 | MEN1 (0.38) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0349219-B1 | 1,2,4,5-benzoylenebis(naphtho[1,8-de]pyrimidine) compounds and their use | SHARP KK (JP) | 1994-10-05 | — | — | EP | disclosed |
| US-5116706-A | As charge generating component | SHARP KABUSHIKI KAISHA (JP) | 1992-05-26 | — | — | US | disclosed |
| EP-0349219-A1 | 1,2,4,5-benzoylenebis(naphtho[1,8-de]pyrimidine) compounds and their use | SHARP KABUSHIKI KAISHA (JP) | 1990-01-03 | — | — | EP | disclosed |