Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 5/20 | 0.44 |
| ▸ | HTR2B | P41595 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10071539 | 0.88 | ALOX15 (0.46) | ADRA2AADRA2BADRA2CHRH3ALOX15 | |
| Hydrochloric Acid SCHEMBL3894376 | 0.81 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CHRH3HRH1 | |
| SCHEMBL31317936 | 0.80 | HTR2C (0.60) | ADRA2AADRA2BADRA2CHRH3HTR2C | |
| SCHEMBL225918 | 0.80 | HTR2C (0.60) | ADRA2AADRA2BADRA2CHRH3HTR2C | |
| SCHEMBL10071531 | 0.79 | ALOX15 (0.42) | ADRA2AADRA2BADRA2CHRH3ALOX15 | |
| Hydrochloric Acid SCHEMBL3694891 | 0.79 | HTR2C (0.58) | ADRA2AADRA2BADRA2CHRH3HTR2C | |
| SCHEMBL21762574 | 0.79 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CHRH3HRH1 | |
| SCHEMBL10071543 | 0.78 | ALOX15 (0.41) | ADRA2AADRA2BADRA2CHRH3ALOX15 | |
| SCHEMBL10071536 | 0.78 | ALOX15 (0.41) | ADRA2AADRA2BADRA2CHRH3ALOX15 | |
| Hydrochloric Acid SCHEMBL21753257 | 0.78 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CHRH3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383247-B1 | Benzazepines with antidopaminergic activity | NOVO NORDISK AS (DK) | 1994-08-03 | — | — | EP | claimed |
| EP-0383247-B1 | Benzazepines with antidopaminergic activity | NOVO NORDISK AS (DK) | 1994-08-03 | — | — | EP | disclosed |
| US-5079243-A | Nervous System Disorders, Antidopaminergic Effect | NOVO NORDISK A/S (DK) | 1992-01-07 | — | — | US | disclosed |