Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326820 | 0.86 | POLB (0.53) | POLBSMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL9404425 | 0.83 | POLB (0.50) | POLBSMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL9404448 | 0.83 | POLB (0.50) | POLBSMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL9404295 | 0.80 | KDM4E (0.48) | POLBSMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL9404529 | 0.80 | CYP1A2 (0.51) | POLBSMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL18421140 | 0.78 | SMN1; SMN2 (0.53) | POLBSMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL4792395 | 0.78 | ALDH1A1 (0.55) | POLBSMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL2726482 | 0.78 | HRH4 (0.50) | POLBSMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL4095134 | 0.77 | KDM4E (0.69) | POLBSMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL2276716 | 0.73 | PIK3CA (0.62) | POLBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371080-A | Central nervous system disorders | NOVO NORDISK A/S | 1994-12-06 | — | — | US | disclosed |
| EP-0619820-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-10-19 | — | — | EP | disclosed |
| WO-1993013103-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-07-08 | — | — | WO | disclosed |