Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404322 | 0.85 | POLB (0.41) | CYP1A2CYP3A4ALOX15TSHRCYP2C19 | |
| SCHEMBL9404233 | 0.85 | HRH4 (0.51) | CYP1A2CYP3A4TSHRCYP2C19USP2 | |
| SCHEMBL9404448 | 0.83 | POLB (0.50) | POLBSMN1; SMN2KDM4EALDH1A1MAPK1 | |
| SCHEMBL7326820 | 0.82 | POLB (0.53) | POLBSMN1; SMN2KDM4EALDH1A1MAPK1 | |
| SCHEMBL9404425 | 0.80 | POLB (0.50) | CYP1A2CYP3A4ALOX15TSHRCYP2C19 | |
| SCHEMBL9404282 | 0.80 | POLB (0.50) | TSHRPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9404295 | 0.80 | KDM4E (0.48) | POLBSMN1; SMN2KDM4EALDH1A1MAPK1 | |
| SCHEMBL4792395 | 0.75 | ALDH1A1 (0.55) | CYP1A2CYP3A4ALOX15TSHRCYP2C19 | |
| SCHEMBL4095134 | 0.74 | KDM4E (0.69) | CYP1A2CYP3A4ALOX15TSHRCYP2C19 | |
| SCHEMBL30615144 | 0.73 | RXFP1 (0.38) | CYP1A2CYP2C19CLK4USP2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371080-A | Central nervous system disorders | NOVO NORDISK A/S | 1994-12-06 | — | — | US | disclosed |
| EP-0619820-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-10-19 | — | — | EP | disclosed |
| WO-1993013103-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-07-08 | — | — | WO | disclosed |