Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 14/20 | 0.52 |
| ▸ | DRD5 | P21918 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | THPO | P40225 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Odapipam SCHEMBL2056522 | 0.87 | DRD1 (0.66) | DRD1DRD5HSD17B10THPODRD2 | |
| Odapipam SCHEMBL7207803 | 0.87 | DRD1 (0.66) | DRD1DRD5HSD17B10THPODRD2 | |
| SCHEMBL7213025 | 0.84 | DRD1 (0.60) | DRD1DRD5HSD17B10THPOMAPK1 | |
| Odapipam SCHEMBL1230030 | 0.83 | DRD1 (0.60) | DRD1DRD5HSD17B10THPODRD2 | |
| SCHEMBL29462305 | 0.83 | DRD1 (0.47) | DRD1DRD5HSD17B10THPOMAPK1 | |
| SCHEMBL7211621 | 0.83 | DRD1 (0.47) | DRD1DRD5HSD17B10THPOMAPK1 | |
| SCHEMBL1648925 | 0.83 | DRD1 (0.47) | DRD1DRD5HSD17B10THPOMAPK1 | |
| Bromide SCHEMBL9405370 | 0.82 | DRD1 (0.47) | DRD1DRD5HSD17B10THPOMAPK1 | |
| SCHEMBL9404251 | 0.81 | CYP3A4 (0.42) | DRD1DRD5HSD17B10THPOMAPK1 | |
| SCHEMBL10695137 | 0.81 | DRD1 (0.64) | DRD1DRD5HSD17B10THPODRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383247-B1 | Benzazepines with antidopaminergic activity | NOVO NORDISK AS (DK) | 1994-08-03 | — | — | EP | disclosed |
| US-5079243-A | Nervous System Disorders, Antidopaminergic Effect | NOVO NORDISK A/S (DK) | 1992-01-07 | — | — | US | disclosed |
| EP-0383247-A1 | Benzazepines with antidopaminergic activity | NOVO NORDISK A/S (DK) | 1990-08-22 | — | — | EP | disclosed |