Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9724653 | 0.86 | CHRM2 (0.49) | CHRM2CHRM1 | |
| Oxalic Acid SCHEMBL9404508 | 0.82 | CHRM2 (0.46) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| Oxalic Acid SCHEMBL9213578 | 0.81 | CHRM2 (0.58) | CHRM2CHRM1 | |
| SCHEMBL9724682 | 0.78 | CHRM2 (0.56) | CHRM2CHRM1 | |
| SCHEMBL9724741 | 0.77 | CHRM2 (0.55) | CHRM2CHRM1 | |
| Oxalic Acid SCHEMBL9404396 | 0.77 | CHRM2 (0.49) | CHRM2CHRM1 | |
| Oxalic Acid SCHEMBL9404516 | 0.76 | CHRM2 (0.48) | CHRM2CHRM1 | |
| SCHEMBL9528809 | 0.74 | CHRM2 (0.51) | CHRM2CHRM1 | |
| SCHEMBL24434414 | 0.73 | CHRM2 (0.50) | CHRM2CHRM1 | |
| SCHEMBL9446706 | 0.73 | CHRM2 (0.50) | CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356912-A | 3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease | NOVO NORDISK A/S (DK) | 1994-10-18 | — | — | US | disclosed |
| US-5262427-A | Cognition activators for Alzheimer*s disease | NOVO NORDISK A/S (DK) | 1993-11-16 | — | — | US | disclosed |
| EP-0316718-B1 | AZACYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-09-15 | — | — | EP | disclosed |
| EP-0316718-A2 | Azacyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1989-05-24 | — | — | EP | disclosed |