Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 6/20 | 0.41 |
| ▸ | CA2 | P00918 | 6/20 | 0.41 |
| ▸ | ACHE | P22303 | 6/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404943 | 0.87 | NPC1 (0.55) | NPC1RAB9ACASP3MAOBPOLB | |
| SCHEMBL9404923 | 0.76 | KMT2A (0.45) | NPC1RAB9AKMT2ACASP3MAOB | |
| SCHEMBL13310231 | 0.74 | NPC1 (0.54) | NPC1RAB9ACASP3MAOBPOLB | |
| SCHEMBL9524227 | 0.70 | NPC1 (0.56) | NPC1RAB9AKMT2AMAOBMEN1 | |
| SCHEMBL5783658 | 0.70 | HTT (0.59) | NPC1RAB9AKMT2AMAOBMEN1 | |
| SCHEMBL5223936 | 0.70 | KMT2A (0.62) | NPC1RAB9AKMT2AMAOBMEN1 | |
| SCHEMBL4210145 | 0.70 | KMT2A (0.56) | NPC1RAB9AKMT2AMAOBMEN1 | |
| SCHEMBL7655197 | 0.70 | RAB9A (0.49) | NPC1RAB9AKMT2ACASP3MAOB | |
| SCHEMBL10163089 | 0.69 | KMT2A (0.58) | NPC1RAB9AKMT2AMAOBMEN1 | |
| SCHEMBL17197477 | 0.69 | QDPR (0.52) | NPC1RAB9AKMT2AMAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0296597-B1 | Hexa-cyclic compound | DAIICHI SEIYAKU CO (JP) | 1994-09-21 | — | — | EP | disclosed |
| US-5061795-A | ANTITUMOR AGENTS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1991-10-29 | — | — | US | disclosed |
| US-4939255-A | Hexa-cyclic camptothecin derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-07-03 | — | — | US | disclosed |
| EP-0296597-A2 | Hexa-cyclic compound | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1988-12-28 | — | — | EP | disclosed |