Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.74 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.74 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.71 |
| ▸ | CHRNG | P07510 | 1/20 | 0.71 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.71 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.71 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.71 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.71 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.71 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.71 |
| ▸ | CHRND | Q07001 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9405507 | 1.00 | SLC6A3 (0.74) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNG | |
| SCHEMBL9405509 | 1.00 | SLC6A3 (0.74) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNG | |
| SCHEMBL5000883 | 0.89 | SLC6A3 (0.74) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNG | |
| SCHEMBL7288917 | 0.89 | SLC6A3 (0.74) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNG | |
| SCHEMBL7288922 | 0.89 | SLC6A3 (0.74) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNG | |
| SCHEMBL5000882 | 0.89 | SLC6A3 (0.74) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNG | |
| SCHEMBL9405574 | 0.88 | SLC6A3 (0.75) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL4996786 | 0.88 | SLC6A3 (0.73) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNG | |
| SCHEMBL4996780 | 0.88 | SLC6A3 (0.73) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNG | |
| SCHEMBL9405578 | 0.88 | SLC6A3 (0.75) | SLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342949-A | Decomposing vinyldiazomethnaes in presence of pyrroles to provide bicyclic ring, which is then reacted with aryl Grignard reagent in presence of copper salt | WAKE FOREST UNIVERSITY (US) | 1994-08-30 | — | — | US | disclosed |
| US-5262428-A | Compounds for treatment of drug dependency | WAKE FOREST UNIVERSITY (US) | 1993-11-16 | — | — | US | disclosed |