Piperine

Piperine

SCHEMBL94058

O=C(/C=C/C=C/c1ccc2c(c1)OCO2)N1CCCCC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 1.00
HPGD P15428 4/20 1.00
KDM4E B2RXH2 4/20 1.00
ALDH1A1 P00352 4/20 1.00
HSD17B10 Q99714 3/20 1.00
TRPV1 Q8NER1 3/20 1.00
CYP3A4 P08684 2/20 1.00
SMN1; SMN2 Q16637 2/20 1.00
NPC1 O15118 2/20 1.00
RAB9A P51151 2/20 1.00
GABRA1 P14867 2/20 1.00
GABRB2 P47870 2/20 1.00
CYP1A2 P05177 2/20 1.00
ALOX5 P09917 2/20 1.00
HDAC6 Q9UBN7 2/20 1.00
CTSD P07339 1/20 1.00
ABCB1 P08183 1/20 1.00
MAOA P21397 1/20 1.00
MAPK1 P28482 1/20 1.00
DHODH Q02127 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Piperine SCHEMBL11434404 1.00 MAOB (1.00) MAOBHPGDKDM4EALDH1A1HSD17B10
Piperine SCHEMBL29370397 1.00 MAOB (1.00) MAOBHPGDKDM4EALDH1A1HSD17B10
Piperine SCHEMBL29369346 1.00 MAOB (1.00) MAOBHPGDKDM4EALDH1A1HSD17B10
Piperine SCHEMBL5309092 1.00 MAOB (1.00) MAOBHPGDKDM4EALDH1A1HSD17B10
SCHEMBL17340450 1.00 MAOB (1.00) MAOBHPGDKDM4EALDH1A1HSD17B10
Piperine SCHEMBL14171509 1.00 MAOB (1.00) MAOBHPGDKDM4EALDH1A1HSD17B10
Piperine SCHEMBL13151642 1.00 MAOB (1.00) MAOBHPGDKDM4EALDH1A1HSD17B10
Piperine SCHEMBL119081 1.00 MAOB (1.00) MAOBHPGDKDM4EALDH1A1HSD17B10
Piperine SCHEMBL29358781 1.00 MAOB (1.00) MAOBHPGDKDM4EALDH1A1HSD17B10
Piperine SCHEMBL94059 1.00 MAOB (1.00) MAOBHPGDKDM4EALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 14183 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144780-A1 COMPOSITION FOR ENHANCING ADRENOMEDULLIN GENE EXPRESSION HOUSE WELLNESS FOODS CORPORATION (JP) 2026-05-28 US claimed
CN-120788206-B Method for improving stability and bioavailability of astaxanthin by combining piperine and whey protein fibril-alginate complex SERICULTURE & AGRI FOOD Research Institute GAAS (CN) 2026-05-26 CN claimed
CN-122094572-A Novel feed additive composition 2026-05-26 CN claimed
WO-2026102866-A1 USE OF COMBINATION OF FGF-2 AND FLAVOKAWAIN C IN PREPARATION OF DRUG FOR TREATING UTERINE ADHESIONS 温州医科大学 2026-05-21 WO claimed
WO-2026105108-A2 AN ERGOTHIONEINE-CURCUMIN SYNERGISTIC ANTI-INFLAMMATORY AND ANTI-AGING COMPLEX COMPOSITION AND A PREPARATION METHOD THEREOF ZIRAOUI ANAS (EG) 2026-05-21 WO claimed
CN-118955455-B Double-target piperine compound used as alpha-glucosidase inhibitor and aldose reductase inhibitor, and preparation method and application thereof 湘潭大学 2026-05-19 CN claimed
US-12629363-B2 Prophylaxis and treatment of angioedema PHARVARIS GMBH (CH) 2026-05-19 US claimed
CN-122030527-A Beverage with function of relieving muscle soreness after exercise and preparation method thereof 一杯本草(西安)健康科技有限公司 2026-05-15 CN claimed
CN-122036865-A Compound and preparation method and application thereof 宁波大学附属第一医院(宁波市第一医院) 2026-05-15 CN claimed
US-20260130395-A1 Water Dispersible Botanical Compositions AQUILA BLACK LTD (AU) 2026-05-14 US claimed
US-4420472-A TOOTHPASTES, MOUTHWASHES INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1983-12-13 US claimed
US-4269862-A ORGANOLEPTIC; PERFUMES, CHEWING GUM, DENTIFRICES, TOBACCO, DETERGENTS AND FABRIC SOFTENERS INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1981-05-26 US claimed
US-4198393-A DENTRIFIRICES, SYNERGISTIC INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1980-04-15 US claimed
US-4197328-A 2-Oxabicyclooctane derivatives in augmenting or enhancing the aroma or taste of foodstuffs INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1980-04-08 US claimed
US-4195100-A Use of 2-oxabicyclooctane derivatives in augmenting or enhancing the flavor of a foodstuff INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1980-03-25 US claimed
US-4195099-A Use of 2-oxabicyclooctane derivatives, for augmenting or enhancing the flavor of foodstuffs INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1980-03-25 US claimed
US-4163068-A Flavoring with terpenyl ethers INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1979-07-31 US claimed
US-4159347-A ETHYLENE GLYCOL OR 1,2-PROPYLENE GLYCOL ACETAL INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1979-06-26 US claimed
US-4139649-A ROAST BEEF INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1979-02-13 US claimed
US-4131687-A Flavoring with terpenyl ethers INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1978-12-26 US claimed