Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | MGMT | P16455 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2449013 | 0.77 | MEN1 (0.45) | BACE1KMT2AMEN1PSMD14PRKACA | |
| SCHEMBL3646079 | 0.77 | ACHE (0.51) | ALDH1A1ABCC8KCNJ11KMT2AKDM4E | |
| SCHEMBL11665903 | 0.76 | MAPT (0.42) | ALDH1A1MAPTGSK3BHASPINKMT2A | |
| SCHEMBL29581128 | 0.76 | MAPT (0.42) | ALDH1A1MAPTGSK3BHASPINKMT2A | |
| SCHEMBL30578394 | 0.74 | KMT2A (0.43) | ALDH1A1MAPTGSK3BHASPINKMT2A | |
| SCHEMBL28231619 | 0.74 | KMT2A (0.43) | ALDH1A1MAPTGSK3BHASPINKMT2A | |
| SCHEMBL15972473 | 0.73 | MAPT (0.41) | ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL8565404 | 0.72 | MAPT (0.42) | ALDH1A1MAPTABCC8KCNJ11PDE7A | |
| SCHEMBL18188660 | 0.72 | ALDH1A1 (0.40) | ALDH1A1MAPTABCC8KCNJ11KMT2A | |
| SCHEMBL11678847 | 0.71 | ALDH1A1 (0.46) | ALDH1A1MAPTPDE7AFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332744-A | Hypotensive, congestive heart failure, intraocular pressure | MERCK & CO., INC. (US) | 1994-07-26 | — | — | US | disclosed |
| US-5157026-A | Oxo-purines as angiotensin II antagonists | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| US-5102880-A | Biphenyl imidazotriazine derivatives; Hypotensive and cardiotonic agents | MERCK & CO., INC. (US) | 1992-04-07 | — | — | US | disclosed |
| EP-0400974-A2 | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1990-12-05 | — | — | EP | disclosed |