Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.56 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28173166 | 0.85 | KMT2A (0.63) | ALDH1A1KMT2AGAAHPGDKDM4E | |
| SCHEMBL9227657 | 0.79 | ALDH1A1 (0.56) | ALDH1A1KMT2AGAAHPGDKDM4E | |
| SCHEMBL2392620 | 0.79 | ALDH1A1 (0.44) | ALDH1A1KMT2AGAAHPGDKDM4E | |
| SCHEMBL4903727 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KMT2AGAAHPGDKDM4E | |
| SCHEMBL9385710 | 0.76 | GAA (0.51) | ALDH1A1KMT2AGAAHPGDKDM4E | |
| SCHEMBL9406598 | 0.76 | TLR8 (0.57) | ALDH1A1KMT2AGAAHPGDKDM4E | |
| SCHEMBL9042231 | 0.74 | ALDH1A1 (0.58) | ALDH1A1KMT2AGAAHPGDKDM4E | |
| SCHEMBL9039144 | 0.74 | ALDH1A1 (0.62) | ALDH1A1KMT2AGAAHPGDKDM4E | |
| SCHEMBL17846912 | 0.74 | IDO1 (0.61) | ALDH1A1KMT2AGAAHPGDKDM4E | |
| SCHEMBL26749714 | 0.72 | ALDH1A1 (0.62) | ALDH1A1KMT2AGAAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0328535-B1 | THE ADMINISTRATION OF MONOAMINE ACRIDINES IN CHOLINERGIC NEURONAL DEFICIT STATES | SUMMERS WILLIAM KOOPMANS (US) | 1994-06-01 | — | — | EP | disclosed |
| EP-0595365-A1 | Pharmaceutical composition for the treatment of underlying nonpharmacologically induced nervous system cholinergic deficit state comprising monoamine acridine derivatives | Summers, William Koopmans (US) | 1994-05-04 | — | — | EP | disclosed |
| US-4816456-A | Administration of monoamine acridines in cholinergic neuronal deficit states | SUMMERS WILLIAM K (US) | 1989-03-28 | — | — | US | disclosed |