Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EEF2K | O00418 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9406604 | 0.76 | NPC1 (0.46) | PRNPRXFP1KDM4EALDH1A1MAPT | |
| SCHEMBL3792562 | 0.75 | PRNP (0.42) | PRNPRXFP1KDM4EALDH1A1MAPT | |
| SCHEMBL9406553 | 0.74 | KDM4E (0.41) | PRNPRXFP1KDM4EALDH1A1MAPT | |
| SCHEMBL9406649 | 0.71 | NPC1 (0.43) | PRNPRXFP1KDM4EALDH1A1MAPT | |
| SCHEMBL15886676 | 0.70 | PRNP (0.52) | PRNPRXFP1KDM4EALDH1A1MAPT | |
| SCHEMBL28306941 | 0.69 | ACHE (0.50) | PRNPRXFP1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL3294700 | 0.69 | KDM4E (0.47) | PRNPRXFP1KDM4EALDH1A1MAPT | |
| SCHEMBL7093937 | 0.68 | BCL2L1 (0.43) | PRNPRXFP1KDM4EALDH1A1MAPT | |
| SCHEMBL9240088 | 0.67 | BCL2L1 (0.42) | PRNPRXFP1KDM4EALDH1A1MEN1 | |
| SCHEMBL10416253 | 0.67 | BCL2L1 (0.42) | PRNPRXFP1KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0328535-B1 | THE ADMINISTRATION OF MONOAMINE ACRIDINES IN CHOLINERGIC NEURONAL DEFICIT STATES | SUMMERS WILLIAM KOOPMANS (US) | 1994-06-01 | — | — | EP | disclosed |
| EP-0595365-A1 | Pharmaceutical composition for the treatment of underlying nonpharmacologically induced nervous system cholinergic deficit state comprising monoamine acridine derivatives | Summers, William Koopmans (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0328535-A4 | THE ADMINISTRATION OF MONOAMINE ACRIDINES IN CHOLINERGIC NEURONAL DEFICIT STATES | — | 1991-05-22 | — | — | EP | disclosed |
| EP-0328535-A1 | THE ADMINISTRATION OF MONOAMINE ACRIDINES IN CHOLINERGIC NEURONAL DEFICIT STATES. | SUMMERS WILLIAM KOOPMANS | 1989-08-23 | — | — | EP | disclosed |
| US-4816456-A | Administration of monoamine acridines in cholinergic neuronal deficit states | SUMMERS WILLIAM K (US) | 1989-03-28 | — | — | US | disclosed |
| WO-1988002256-A1 | THE ADMINISTRATION OF MONOAMINE ACRIDINES IN CHOLINERGIC NEURONAL DEFICIT STATES | SUMMERS WILLIAM KOOPMANS (US) | 1988-04-07 | — | — | WO | disclosed |