Praxadine

Praxadine

SCHEMBL94070

N=C(N)n1cccn1

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Praxadine SCHEMBL3086435 0.98
Praxadine SCHEMBL28203296 0.98
Praxadine SCHEMBL3579034 0.98 NOS1 (0.95)
Praxadine SCHEMBL52095 0.98
Praxadine SCHEMBL5396070 0.86 NOS1 (0.74)
Praxadine SCHEMBL8132131 0.84 NOS1 (0.71)
Praxadine SCHEMBL31705643 0.84
Praxadine SCHEMBL2301207 0.82 NOS1 (0.67)
SCHEMBL14936408 0.79 NOS1 (0.65)
SCHEMBL5378534 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2107 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113383039-B Moisture curable polyolefin formulation 陶氏环球技术有限责任公司 2023-09-26 CN claimed
US-20230272006-A1 PEPTIDOMIMETICS AND METHOD OF SYNTHESIS THEREOF THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2023-08-31 US claimed
US-20230100243-A1 PEPTIDOMIMETICS AND METHOD OF SYNTHESIS THEREOF THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2023-03-30 US claimed
CN-114957176-A Human angiotensin converting enzyme inhibitor compound and synthetic method 河南中医药大学第一附属医院 2022-08-30 CN claimed
US-20220098432-A1 MOISTURE-CURABLE POLYOLEFIN FORMULATION DOW GLOBAL TECHNOLOGIES LLC (US) 2022-03-31 US claimed
CN-113383039-A Moisture curable polyolefin formulations 陶氏环球技术有限责任公司 2021-09-10 CN claimed
EP-3448864-B1 SILSESQUIOXANES AS TRANSPORT COMPOUNDS UNIV DARMSTADT TECH (DE) 2021-06-23 EP claimed
CN-108752241-B Acylguanidines for the treatment of arthrosis 默克专利股份公司 2021-03-12 CN claimed
CN-111208245-A Protein N-terminal peptide segment reverse enrichment method based on guanidination marker 中国科学院大连化学物理研究所 2020-05-29 CN claimed
EP-2823810-B9 Amphoteric liposomes comprising imino lipids NOVOSOM VERWALTUNGS GMBH (DE) 2019-10-30 EP claimed
WO-1997008165-A1 NEW CYCLIC GUANIDINES, PROCESS FOR PREPARING THE SAME AND MEDICAMENTS BOEHRINGER MANNHEIM GMBH (DE) 1997-03-06 WO claimed
EP-0743320-A2 Acyl guanidine and amidine prodrugs BRISTOL-MYERS SQUIBB COMPANY (US) 1996-11-20 EP claimed
EP-0662967-A1 SYNTHESIS OF N-ACETYL NEURAMINIC ACID DERIVATIVES BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) 1995-07-19 EP claimed
WO-1994007886-A1 SYNTHESIS OF N-ACETYL NEURAMINIC ACID DERIVATIVES GLAXO GROUP LIMITED (GB) 1994-04-14 WO claimed
EP-0433526-A1 Medicine for the treatment of heart-circulatory illnesses, of arrhythmics in particular Richter, Peter, Prof. Dr.sc.nat. (DE) 1991-06-26 EP claimed
US-4908454-A Reacting aminothiazole compound in the presence of a Lewis acid with an amidinopyrazole YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1990-03-13 US claimed
EP-0133234-B1 IMIDAZOQUINAZOLIN-2-ONE COMPOUNDS PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS DAIICHI SEIYAKU CO., LTD. (JP) 1989-04-12 EP claimed
EP-0129258-B1 IMIDAZOQUINAZOLINE COMPOUND DAIICHI SEIYAKU CO., LTD. (JP) 1987-09-23 EP claimed
EP-0133234-A2 Imidazoquinazolin-2-one compounds process for their production and pharmaceutical compositions containing said compounds DAIICHI SEIYAKU CO., LTD. (JP) 1985-02-20 EP claimed
EP-0129258-A1 Imidazoquinazoline compound DAIICHI SEIYAKU CO., LTD. (JP) 1984-12-27 EP claimed