SCHEMBL9407409

SCHEMBL9407409

[SiH3]c1n[nH]c2ccccc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.60
GAA P10253 2/20 0.60
PDPK1 O15530 1/20 0.60
CYP3A4 P08684 1/20 0.60
IDO1 P14902 3/20 0.56
ALDH1A1 P00352 3/20 0.56
ALPL P05186 1/20 0.56
HPGD P15428 1/20 0.56
TTK P33981 1/20 0.56
MAPK10 P53779 1/20 0.56
CYP1A2 P05177 1/20 0.50
LRRK2 Q5S007 2/20 0.47
NPC1 O15118 1/20 0.47
TP53 P04637 1/20 0.47
RAB9A P51151 1/20 0.47
YTHDC1 Q96MU7 1/20 0.44
FGFR1 P11362 1/20 0.44
FLT1 P17948 1/20 0.44
AURKA O14965 1/20 0.44
ITK Q08881 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1672674 0.77 IDO1 (0.78) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL18878 0.75 PDPK1 (1.00) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL29481432 0.75 PDPK1 (1.00) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL2561174 0.73 KDM4E (0.58) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL61457 0.73 KDM4E (0.58) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL1012344 0.73 KDM4E (0.58) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL6461006 0.73 KDM4E (0.58) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL276725 0.73 KDM4E (0.58) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL329139 0.73 KDM4E (0.58) KDM4EGAAPDPK1CYP3A4IDO1
SCHEMBL962678 0.73 KDM4E (0.58) KDM4EGAAPDPK1CYP3A4IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-6293779-A None JP disclosed
JP-H06293779-A NEW INDAZOLE SILANE COMPOUND, ITS PRODUCTION AND METAL SURFACE TREATING AGENT CONTAINING THE COMPOUND JAPAN ENERGY CORP 1994-10-21 JP disclosed