SCHEMBL9408142

SCHEMBL9408142

CC(=O)N1CCc2sc(CCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 9/20 0.56
SLC6A4 P31645 1/20 0.56
ACHE P22303 2/20 0.55
HTR2A P28223 11/20 0.54
HTR7 P34969 10/20 0.54
DRD3 P35462 1/20 0.54
KCNH2 Q12809 9/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8917299 0.94 DRD2 (0.56) DRD2SLC6A4ACHEHTR2AHTR7
SCHEMBL8917984 0.91 HTR2A (0.55) DRD2SLC6A4ACHEHTR2AHTR7
Hydrochloric Acid SCHEMBL8991836 0.90 HTR2A (0.55) DRD2SLC6A4ACHEHTR2AHTR7
SCHEMBL8917663 0.87 MCHR1 (0.62) DRD2SLC6A4HTR2ADRD3KCNH2
Oxalic Acid SCHEMBL8917846 0.87 DRD2 (0.54) DRD2SLC6A4ACHEHTR2ADRD3
SCHEMBL8917929 0.86 DRD2 (0.54) DRD2SLC6A4ACHEHTR2AHTR7
SCHEMBL8916147 0.84 DRD2 (0.54) DRD2SLC6A4ACHEHTR2AHTR7
SCHEMBL8917101 0.84 DRD2 (0.54) DRD2SLC6A4ACHEHTR2AHTR7
SCHEMBL8916632 0.83 DRD2 (0.54) DRD2SLC6A4ACHEHTR2AHTR7
SCHEMBL8920271 0.83 DRD2 (0.56) DRD2SLC6A4ACHEHTR2AHTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596125-A1 CONDENSED THIOPHENE COMPOUND AND PHARMACEUTICAL USE THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1994-05-11 EP disclosed