SCHEMBL9408653

SCHEMBL9408653

O=[N+]([O-])C=C1N=CCN1Cc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.41
CHRNA1 P02708 1/20 0.39
CHRNA3 P32297 1/20 0.39
CHRNA7 P36544 1/20 0.39
ALDH1A1 P00352 4/20 0.37
MAPT P10636 4/20 0.37
KMT2A Q03164 3/20 0.37
HTT P42858 2/20 0.37
HSP90AA1 P07900 2/20 0.37
MEN1 O00255 2/20 0.37
CYP2D6 P10635 2/20 0.37
CYP2C9 P11712 2/20 0.37
CYP2C19 P33261 2/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
ATM Q13315 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
KDM4E B2RXH2 1/20 0.36
CHRNB2 P17787 1/20 0.36
CHRNA4 P43681 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10510895 0.82 SMN1; SMN2 (0.64) SMN1; SMN2CHRNA1CHRNA3CHRNA7ALDH1A1
SCHEMBL10867211 0.82 SMN1; SMN2 (0.38) SMN1; SMN2CHRNA1CHRNA3CHRNA7CHRNB2
SCHEMBL9408700 0.81 KCNJ1 (0.42) SMN1; SMN2ALDH1A1KMT2AL3MBTL1KCNH2
SCHEMBL9408588 0.80 SMN1; SMN2 (0.42) SMN1; SMN2CHRNA1CHRNA3CHRNA7ALDH1A1
SCHEMBL10506559 0.79 SMN1; SMN2 (0.46) SMN1; SMN2CHRNA1CHRNA3CHRNA7ALDH1A1
SCHEMBL10573632 0.76 SMN1; SMN2 (0.36) SMN1; SMN2CHRNA1CHRNA3CHRNA7
SCHEMBL9408578 0.76 SMN1; SMN2 (0.34) SMN1; SMN2CHRNA1CHRNA3CHRNA7CYP3A4
SCHEMBL4101769 0.73 DDB1 (0.46) ALDH1A1MAPTKMT2AMEN1CYP2D6
SCHEMBL12373561 0.72 SMN1; SMN2 (0.67) SMN1; SMN2CHRNA1CHRNA3CHRNA7ALDH1A1
SCHEMBL1866150 0.72 SMN1; SMN2 (0.67) SMN1; SMN2CHRNA1CHRNA3CHRNA7ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0623601-A1 N-(3-Fluorobenzyl)heterocyclic derivatives and their use as pesticides SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1994-11-09 EP disclosed