Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.58 |
| ▸ | JAK1 | P23458 | 4/20 | 0.58 |
| ▸ | TYK2 | P29597 | 4/20 | 0.58 |
| ▸ | JAK3 | P52333 | 4/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.51 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9409146 | 0.94 | JAK2 (0.54) | JAK2JAK1TYK2JAK3AKR1C3 | |
| SCHEMBL11648254 | 0.82 | AKR1C3 (0.76) | JAK2JAK1TYK2JAK3AKR1C3 | |
| SCHEMBL9409083 | 0.81 | MAPT (0.61) | HSD17B10ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL30379236 | 0.80 | JAK2 (0.67) | JAK2JAK1TYK2JAK3AKR1C3 | |
| SCHEMBL29127153 | 0.80 | JAK2 (0.67) | JAK2JAK1TYK2JAK3AKR1C3 | |
| SCHEMBL9409100 | 0.79 | MAPT (0.59) | HSD17B10ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3191755 | 0.78 | MAPT (0.69) | AKR1C3AKR1C2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9409050 | 0.78 | CSF1R (0.49) | AKR1C3AKR1C2HSD17B10ALDH1A1KDM4E | |
| SCHEMBL9409108 | 0.77 | TSHR (0.51) | HSD17B10ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL11644754 | 0.77 | AKR1C3 (0.68) | AKR1C3AKR1C2HSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | claimed |
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | disclosed |