Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.54 |
| ▸ | JAK1 | P23458 | 4/20 | 0.54 |
| ▸ | TYK2 | P29597 | 4/20 | 0.54 |
| ▸ | JAK3 | P52333 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9409042 | 0.94 | JAK2 (0.58) | JAK2JAK1TYK2JAK3HSD17B10 | |
| SCHEMBL9409100 | 0.87 | MAPT (0.59) | HSD17B10KDM4EMAPTALDH1A1GAA | |
| SCHEMBL9409083 | 0.85 | MAPT (0.61) | HSD17B10KDM4EMAPTALDH1A1GAA | |
| SCHEMBL9409337 | 0.84 | CSF1R (0.49) | HSD17B10KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL9409108 | 0.84 | TSHR (0.51) | HSD17B10KDM4EMAPTALDH1A1GAA | |
| SCHEMBL9409163 | 0.83 | MAPT (0.50) | HSD17B10KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL9409047 | 0.83 | MAPT (0.55) | KDM4EMAPTHPGDAKR1C3AKR1C2 | |
| SCHEMBL9409103 | 0.82 | ALDH1A1 (0.50) | HSD17B10KDM4EMAPTALDH1A1GAA | |
| SCHEMBL9409202 | 0.81 | MAPT (0.64) | HSD17B10MAPTALDH1A1GAAAKR1C3 | |
| SCHEMBL9409063 | 0.80 | GAA (0.46) | HSD17B10KDM4EMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | disclosed |