SCHEMBL941074

SCHEMBL941074

COc1[c]c(C(F)(F)F)nc(N)n1

nearest known ligand 0.34

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.34
HSP90AA1 P07900 1/20 0.32
HSP90AB1 P08238 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL939126 0.80 KDM4E (0.36) KDM4EHSP90AA1HSP90AB1
SCHEMBL939883 0.78 HSD17B10 (0.33)
SCHEMBL940350 0.78
SCHEMBL940362 0.76 MAPK1 (0.31)
SCHEMBL938363 0.74 KDM4E (0.37) KDM4E
SCHEMBL939694 0.74
SCHEMBL939965 0.72
SCHEMBL8307495 0.60
SCHEMBL5998835 0.60 LMNA (0.41) KDM4EHSP90AA1HSP90AB1
SCHEMBL5891451 0.58 HSP90AA1 (0.58) KDM4EHSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7875606-B2 Herbicides; selectivity between crops and weeds IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2011-01-25 US disclosed
EP-1405853-B1 ISOXAZOLINE DERIVATIVES AND HERBICIDES KUMIAI CHEMICAL INDUSTRY CO (JP) 2010-11-03 EP disclosed
EP-1405853-A1 ISOXAZOLINE DERIVATIVES AND HERBICIDES KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2004-04-07 EP disclosed