Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Berberine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.90 |
| ▸ | BCHE | P06276 | 9/20 | 0.90 |
| ▸ | EP300 | Q09472 | 5/20 | 0.90 |
| ▸ | LMNA | P02545 | 3/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.90 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.90 |
| ▸ | MAPT | P10636 | 3/20 | 0.90 |
| ▸ | RAD52 | P43351 | 3/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.90 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.90 |
| ▸ | DRD2 | P14416 | 2/20 | 0.90 |
| ▸ | TSHR | P16473 | 2/20 | 0.90 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.90 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.90 |
| ▸ | RXRA | P19793 | 2/20 | 0.90 |
| ▸ | DRD1 | P21728 | 2/20 | 0.90 |
| ▸ | HTR2B | P41595 | 2/20 | 0.90 |
| ▸ | HTT | P42858 | 2/20 | 0.90 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.90 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Berberine SCHEMBL29570291 | 0.96 | BCHE (0.87) | ACHEBCHEEP300LMNACYP3A4 | |
| Berberine SCHEMBL231967 | 0.96 | BCHE (0.87) | ACHEBCHEEP300LMNACYP3A4 | |
| Berberine SCHEMBL15672948 | 0.95 | BCHE (0.85) | ACHEBCHEEP300LMNACYP3A4 | |
| Berberine SCHEMBL15669190 | 0.95 | ACHE (1.00) | ACHEBCHEEP300LMNACYP3A4 | |
| Berberine SCHEMBL29354144 | 0.95 | ACHE (1.00) | ACHEBCHEEP300LMNACYP3A4 | |
| Berberine SCHEMBL30153843 | 0.95 | ACHE (1.00) | ACHEBCHEEP300LMNACYP3A4 | |
| Berberine SCHEMBL25632 | 0.95 | ACHE (1.00) | ACHEBCHEEP300LMNACYP3A4 | |
| Berberine SCHEMBL16781367 | 0.94 | ACHE (0.90) | ACHEBCHEEP300LMNACYP3A4 | |
| Berberine SCHEMBL2538316 | 0.94 | ACHE (0.98) | ACHEBCHEEP300LMNACYP3A4 | |
| Berberine SCHEMBL21462194 | 0.94 | ACHE (0.98) | ACHEBCHEEP300LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1518 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119699475-A | Use of berberine alkaloid in preventing and/or treating intestinal diseases | IRP健康股份有限公司 | 2025-03-28 | — | — | CN | claimed |
| CN-115707467-B | Pharmaceutical composition comprising berberine and metformin and its use for treating or preventing atherosclerosis | 中国医学科学院药物研究所 | 2024-11-05 | — | — | CN | claimed |
| WO-2023164252-A1 | ISOTHERMAL NUCLEIC ACID DETECTION ASSAYS AND USES THEREOF | TRUSTEES OF BOSTON UNIVERSITY (US) | 2023-08-31 | — | — | WO | claimed |
| CN-115779988-A | Method and apparatus for detecting the presence of particles | 英雄科学有限公司 | 2023-03-14 | — | — | CN | claimed |
| CN-114042100-A | Antibacterial composition containing traditional Chinese medicine extract and application thereof | 湖南农业大学 | 2022-02-15 | — | — | CN | claimed |
| CN-112543635-A | Nitroimidazole formulations | IRP健康股份有限公司 | 2021-03-23 | — | — | CN | claimed |
| CN-111939156-A | Combined antibacterial pharmaceutical composition and application thereof | 天津现代创新中药科技有限公司 | 2020-11-17 | — | — | CN | claimed |
| CN-111205285-A | Purification method and crystal form of berberine or berberine salt | 江西富祥药业股份有限公司 | 2020-05-29 | — | — | CN | claimed |
| CN-110938045-A | Broad-spectrum bactericidal pollution-free growth-promoting compound and composition thereof | 刘力 | 2020-03-31 | — | — | CN | claimed |
| CN-110823881-A | Method for measuring montmorillonite adsorption force by using berberine sulfate | 刘圣梅 | 2020-02-21 | — | — | CN | claimed |
| EP-2330908-A1 | FLUORESCENT CDK INHIBITORS FOR TREATMENT OF CANCER | Georgetown University (US) | 2011-06-15 | — | — | EP | claimed |
| CN-102058638-A | Compound andrographis paniculata injection for treating yellow-white dysentery of piglet and preparation method thereof | HENAN YAWEI ANIMAL PHARMACEUTICAL CO LTD | 2011-05-18 | — | — | CN | claimed |
| WO-2010019967-A1 | FLUORESCENT CDK INHIBITORS FOR TREATMENT OF CANCER | GEORGETOWN UNIVERSITY (US) | 2010-02-18 | — | — | WO | claimed |
| CN-101375947-A | Compound Macleaya cordata injection and preparation method | TIANJIN SHENGJI GROUP CO LTD (CN) | 2009-03-04 | — | — | CN | claimed |
| CN-100411631-C | Orally administered compound antihyperlipidemic | ZHUJIANG HOSPITAL SOUTHERN MED (CN) | 2008-08-20 | — | — | CN | claimed |
| CN-101007006-A | Compound berberine sulphate injection and its preparation method | TIANJIN SHENGJI GROUP CO LTD (CN) | 2007-08-01 | — | — | CN | claimed |
| CN-1872027-A | Injection of vitriolic berberine for animal use, preparation and usage | SHENGJI CO LTD TIANJIN (CN) | 2006-12-06 | — | — | CN | claimed |
| CN-1771944-A | Application of high-solubility berberine in preparing medicine | WU KAIMIN (CN) | 2006-05-17 | — | — | CN | claimed |
| CN-1197588-C | Externally applied agent for treating skin suppuration infection | WANG SHANBAI (CN) | 2005-04-20 | — | — | CN | claimed |
| US-6551628-B1 | Herbal intestinal tract cleanser | RENEW LIFE FORMULAS, INC. | 2003-04-22 | — | — | US | claimed |