Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 1.00 |
| ▸ | BCHE | P06276 | 9/20 | 1.00 |
| ▸ | EP300 | Q09472 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | RAD52 | P43351 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 2/20 | 1.00 |
| ▸ | RXRA | P19793 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | HTR2B | P41595 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Berberine SCHEMBL30153843 | 1.00 | ACHE (1.00) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL29354144 | 1.00 | ACHE (1.00) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL15669190 | 1.00 | ACHE (1.00) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL3686644 | 0.99 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL21462194 | 0.99 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL1376273 | 0.99 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL2538316 | 0.99 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL153906 | 0.99 | ACHE (1.00) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL10709599 | 0.99 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL4894622 | 0.99 | BCHE (0.98) | ACHEBCHEEP300CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 34344 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122076506-A | Composite catalyst for synthesizing berberine intermediate piperonylethylamine and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075441-A | Nanoparticle for loading dihydro berberine as well as preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122094572-A | Novel feed additive composition | — | 2026-05-26 | — | — | CN | claimed |
| CN-122074590-A | Preparation method of sheep Zhuang powder | — | 2026-05-26 | — | — | CN | claimed |
| CN-122094685-A | Use of dihydroberberine or derivatives thereof for regulating or improving emotion | — | 2026-05-26 | — | — | CN | claimed |
| US-20260137663-A1 | ADMINISTRATION OF R-BETA-HYDROXYBUTYRATE SALT BLEND AND RELATED COMPOUNDS IN HUMANS | AXCESS GLOBAL SCIENCES LLC (US) | 2026-05-21 | — | — | US | claimed |
| US-20260137806-A1 | INTERCALATING SUGAR MOLECULES | XALUD THERAPEUTICS, INC. (US) | 2026-05-21 | — | — | US | claimed |
| CN-122056926-A | Probiotic composition containing melatonin and application of composition in sleep | 南京北极光生物科技有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-12629336-B2 | Compositions and methods of use thereof for treatment of mastitis | CUREMAST, INC. (US) | 2026-05-19 | — | — | US | claimed |
| US-12629363-B2 | Prophylaxis and treatment of angioedema | PHARVARIS GMBH (CH) | 2026-05-19 | — | — | US | claimed |
| EP-0071999-B1 | METHOD FOR PRODUCING SECONDARY METABOLITES OF PLANTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-03-26 | — | — | EP | claimed |
| EP-0108147-A4 | Use of a protoberberine alkaloid and composition containing same. | MAROKO PETER R | 1984-09-13 | — | — | EP | claimed |
| EP-0108147-A1 | Use of a protoberberine alkaloid and composition containing same. | MAROKO PETER R | 1984-05-16 | — | — | EP | claimed |
| WO-1983003970-A1 | COMPOUNDS, COMPOSITIONS AND METHOD OF TREATMENT FOR IMPROVING CIRCULATORY PERFORMANCE | MAROKO PETER R | 1983-11-24 | — | — | WO | claimed |
| EP-0003583-B1 | COMPOSITIONS FOR CYTOCHEMICAL INVESTIGATION, THEIR USE AND METHOD FOR THE DETECTION OF STEROID HORMONE RECEPTORS IN HUMAN TISSUES | Lee, Sin Hang (US) | 1981-12-02 | — | — | EP | claimed |
| US-4215102-A | Cytochemical agents and methods for the detection of steroid hormone receptors in human tissues | LEE SIN H | 1980-07-29 | — | — | US | claimed |
| US-4200629-A | BERBERINE ALKALOIDS, PHOSPHATES | NAKAMURA JUNICHI | 1980-04-29 | — | — | US | claimed |
| EP-0003583-A1 | Compositions for cytochemical investigation, their use and method for the detection of steroid hormone receptors in human tissues | Lee, Sin Hang (US) | 1979-08-22 | — | — | EP | claimed |
| US-4087426-A | Oxybisberberine and a process for its production | RESEARCH CORPORATION (US) | 1978-05-02 | — | — | US | claimed |
| US-3943251-A | Ophthamological use of hydrastis compounds | MEDOW NORMAN B | 1976-03-09 | — | — | US | claimed |