Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.41 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9412587 | 0.87 | JAK2 (0.42) | HDAC6HDAC1BRD4ITGB3ITGA2B | |
| SCHEMBL9412623 | 0.83 | MAPT (0.46) | HDAC6BRD4ITGB3ITGA2BITGA2 | |
| SCHEMBL9249332 | 0.83 | JAK2 (0.53) | BRD4ITGB3ITGA2BITGA2JAK2 | |
| SCHEMBL9412546 | 0.82 | NLRP3 (0.42) | HDAC6BRD4ITGB3ITGA2BITGA2 | |
| SCHEMBL9412491 | 0.82 | HDAC6 (0.45) | HDAC6HDAC1BRD4ITGB3ITGA2B | |
| SCHEMBL9412665 | 0.82 | MAPT (0.45) | HDAC6BRD4ITGB3ITGA2BITGA2 | |
| SCHEMBL9412632 | 0.82 | HDAC6 (0.42) | HDAC6JAK2JAK1TYK2JAK3 | |
| SCHEMBL9412547 | 0.81 | HPGD (0.43) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL9412452 | 0.81 | MAPT (0.44) | HDAC6BRD4ITGB3ITGA2BITGA2 | |
| SCHEMBL9412592 | 0.80 | HDAC6 (0.43) | HDAC6HDAC1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611660-A2 | Condensed 5-membered heterocycles, process for their preparation and medicines containing these compounds | Dr. Karl Thomae GmbH (DE) | 1994-08-24 | — | — | EP | disclosed |