Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9412665 | 0.95 | MAPT (0.45) | MAPTITGB3ITGA2BPOLBITGA2 | |
| SCHEMBL9412511 | 0.95 | MAPT (0.45) | MAPTITGB3ITGA2BPOLBITGA2 | |
| SCHEMBL9412452 | 0.94 | MAPT (0.44) | MAPTITGB3ITGA2BPOLBITGA2 | |
| SCHEMBL9412536 | 0.93 | ITGB3 (0.46) | MAPTITGB3ITGA2BPOLBITGA2 | |
| SCHEMBL9188544 | 0.91 | ITGB3 (0.57) | MAPTITGB3ITGA2BPOLBITGA2 | |
| SCHEMBL9412583 | 0.90 | MAPT (0.47) | MAPTPOLBNPC1RAB9ASMN1; SMN2 | |
| Bromide SCHEMBL9412462 | 0.90 | ITGB3 (0.56) | MAPTITGB3ITGA2BPOLBITGA2 | |
| SCHEMBL9412612 | 0.90 | ITGB3 (0.42) | MAPTITGB3ITGA2BPOLBITGA2 | |
| SCHEMBL9412727 | 0.90 | POLB (0.46) | MAPTITGB3ITGA2BPOLBITGA2 | |
| SCHEMBL9412586 | 0.90 | RORC (0.46) | ITGB3ITGA2BITGA2ROCK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611660-A2 | Condensed 5-membered heterocycles, process for their preparation and medicines containing these compounds | Dr. Karl Thomae GmbH (DE) | 1994-08-24 | — | — | EP | claimed |
| EP-0611660-A2 | Condensed 5-membered heterocycles, process for their preparation and medicines containing these compounds | Dr. Karl Thomae GmbH (DE) | 1994-08-24 | — | — | EP | disclosed |