Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236381 | 0.85 | LMNA (0.53) | KMT2APARP1MAPK1KDM4ELMNA | |
| SCHEMBL9675030 | 0.81 | PARP1 (0.53) | KMT2APARP1MAPK1KDM4ELMNA | |
| SCHEMBL1542104 | 0.78 | SMN1; SMN2 (0.55) | KMT2AMAPK1KDM4ELMNAALDH1A1 | |
| SCHEMBL8767256 | 0.76 | SMN1; SMN2 (0.57) | KMT2APARP1MAPK1KDM4ELMNA | |
| SCHEMBL15002455 | 0.75 | AKR1C3 (0.55) | PARP1MAPK1LMNA | |
| SCHEMBL28917493 | 0.74 | SMN1; SMN2 (0.50) | KMT2AMAPK1KDM4ELMNAALDH1A1 | |
| SCHEMBL8213702 | 0.73 | PDE4A (0.54) | PARP1MAPK1LMNAALDH1A1POLB | |
| SCHEMBL15001764 | 0.72 | MRGPRX4 (0.55) | KMT2APARP1SMN1; SMN2 | |
| SCHEMBL16488685 | 0.71 | PARP1 (0.52) | PARP1KDM4E | |
| SCHEMBL17356392 | 0.71 | PARP1 (0.52) | KMT2APARP1MAPK1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4400509-A | WITH HEXAMETHYLDISILANE WITH AN ORGANONITROGEN CATALYST | GIST-BROCADES N.V. (NL) | 1983-08-23 | — | — | US | claimed |
| EP-0043630-A2 | Improved process for the silylation of organic compounds with 1,1,1-trimethyl-N-(trimethylsilyl)silanamine by means of catalysis with certain nitrogen containing compounds | GIST-BROCADES N.V. (NL) | 1982-01-13 | — | — | EP | claimed |
| EP-0611770-A2 | A process for preparing acid halides | ELI LILLY AND COMPANY (US) | 1994-08-24 | — | — | EP | disclosed |
| US-5084568-A | Process for preparing acid halides | ELI LILLY AND COMPANY (US) | 1992-01-28 | — | — | US | disclosed |
| US-5013854-A | Process for preparing acid halides | ELI LILLY AND COMPANY (US) | 1991-05-07 | — | — | US | disclosed |
| EP-0381451-A1 | A process for preparing acid halides | ELI LILLY AND COMPANY (US) | 1990-08-08 | — | — | EP | disclosed |
| US-4400509-A | WITH HEXAMETHYLDISILANE WITH AN ORGANONITROGEN CATALYST | GIST-BROCADES N.V. (NL) | 1983-08-23 | — | — | US | disclosed |
| US-4379923-A | Preparation of 7-acylamino-3-(thio-substituted)-methyl 3-cephem-4-carboxylic acid-1-oxide derivatives | GIST-BROCADES N.V. (NL) | 1983-04-12 | — | — | US | disclosed |
| EP-0047560-A2 | Process for the preparation of 7-acylamino-3-(thio-substituted)methyl-3-cephem-4-carboxylic acid 1-oxide derivatives | GIST-BROCADES N.V. (NL) | 1982-03-17 | — | — | EP | disclosed |
| EP-0043630-A2 | Improved process for the silylation of organic compounds with 1,1,1-trimethyl-N-(trimethylsilyl)silanamine by means of catalysis with certain nitrogen containing compounds | GIST-BROCADES N.V. (NL) | 1982-01-13 | — | — | EP | disclosed |