Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 10/20 | 0.53 |
| ▸ | LTB4R2 | Q9NPC1 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | PDE5A | O76074 | 9/20 | 0.52 |
| ▸ | PDE1A | P54750 | 5/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417862 | 0.86 | PDE5A (0.60) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL9417946 | 0.82 | LTB4R (0.53) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL9417912 | 0.82 | LTB4R (0.58) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL9417807 | 0.82 | LTB4R (0.56) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL9417890 | 0.81 | PDE5A (0.56) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL6802277 | 0.80 | LTB4R (0.58) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL9417872 | 0.80 | NR1H4 (0.53) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL9417844 | 0.80 | LTB4R (0.54) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL10346817 | 0.80 | NR1H4 (0.66) | LTB4RLTB4R2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL9735250 | 0.79 | CNR2 (0.41) | PDE5APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294613-A | Benzene derivatives of p-substituted ether and acid or ester | ELI LILLY AND COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| US-4945099-A | LEUKOTRIENE ANTAGONIST | ELI LILLY AND COMPANY (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0276065-B1 | ANTI-INFLAMMATORY AGENTS | ELI LILLY AND COMPANY (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0276065-A1 | Anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1988-07-27 | — | — | EP | disclosed |