Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.52 |
| ▸ | PPARA | Q07869 | 3/20 | 0.50 |
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417753 | 0.98 | ALOX5 (0.53) | ALOX5PPARAPPARGHTR2APTGS2 | |
| SCHEMBL9417818 | 0.95 | ALOX5 (0.47) | ALOX5PPARAPPARGHTR2APTGS2 | |
| SCHEMBL15174365 | 0.85 | PPARA (0.51) | ALOX5PPARAPPARGHTR2APTGS2 | |
| SCHEMBL15174646 | 0.82 | HTR2A (0.51) | ALOX5PPARAPPARGHTR2APTGS2 | |
| SCHEMBL48126 | 0.78 | CYP3A4 (0.45) | HTR2ACYP3A4TSHR | |
| SCHEMBL9453971 | 0.78 | HTR2A (0.47) | ALOX5PPARAPPARGHTR2ACYP3A4 | |
| SCHEMBL13098212 | 0.77 | ALOX5 (0.51) | ALOX5PPARAPTGS2TSHR | |
| SCHEMBL11897974 | 0.77 | CYP3A4 (0.50) | HTR2ACYP3A4TSHR | |
| SCHEMBL13596109 | 0.77 | CYP3A4 (0.50) | HTR2ACYP3A4TSHR | |
| SCHEMBL9739173 | 0.76 | NR1H4 (0.47) | PPARACYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294613-A | Benzene derivatives of p-substituted ether and acid or ester | ELI LILLY AND COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| US-5098613-A | Aromatic ethers for treatment of mammals | ELI LILLY AND COMPANY (US) | 1992-03-24 | — | — | US | disclosed |
| US-4945099-A | LEUKOTRIENE ANTAGONIST | ELI LILLY AND COMPANY (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0276065-B1 | ANTI-INFLAMMATORY AGENTS | ELI LILLY AND COMPANY (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0276065-A1 | Anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1988-07-27 | — | — | EP | disclosed |