Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 4/20 | 0.40 |
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9419031 | 0.81 | MAPT (0.53) | NPC1RAB9AMAPTHSD17B1PGR | |
| SCHEMBL12619017 | 0.78 | ALDH1A1 (0.53) | MAPTCNR1CNR2CA1CA2 | |
| SCHEMBL9418956 | 0.77 | RARG (0.61) | NPC1RAB9AKDM4E | |
| SCHEMBL9418959 | 0.77 | RARG (0.61) | NPC1RAB9AKDM4E | |
| SCHEMBL9418960 | 0.75 | MAPT (0.55) | NPC1RAB9AMAPTHSD17B1PGR | |
| SCHEMBL17926682 | 0.74 | MAPT (0.46) | NPC1RAB9AMAPTHSD17B1PGR | |
| SCHEMBL15927508 | 0.74 | GSK3B (0.47) | CNR1CNR2 | |
| SCHEMBL15927440 | 0.74 | CNR1 (0.47) | NPC1RAB9AMAPTCNR1CNR2 | |
| SCHEMBL21584068 | 0.72 | NPC1 (0.67) | NPC1RAB9AMAPTHSD17B1HPGD | |
| SCHEMBL29793289 | 0.72 | NPC1 (0.67) | NPC1RAB9AMAPTHSD17B1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315071-B1 | Benzocyclohepten derivatives, their preparation and utilisation for pharmaceutics | HOFFMANN LA ROCHE (CH) | 1994-07-20 | — | — | EP | disclosed |
| US-4992574-A | Skin disorders, antiallergens, antiinflammatory agent | HOFFMANN-LA ROCHE INC. (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0315071-A2 | Benzocyclohepten derivatives, their preparation and utilisation for pharmaceutics | F. HOFFMANN-LA ROCHE AG (CH) | 1989-05-10 | — | — | EP | disclosed |