Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014802 | 0.85 | TSHR (0.44) | NPC1RAB9AATMTDP1VCAM1 | |
| SCHEMBL973982 | 0.85 | NPC1 (0.43) | NPC1RAB9AATMTDP1VCAM1 | |
| SCHEMBL31468684 | 0.83 | CA12 (0.46) | NPC1RAB9AATMTDP1VCAM1 | |
| SCHEMBL9878340 | 0.83 | KMT2A (0.53) | NPC1RAB9AATMTDP1VCAM1 | |
| Hydrochloric Acid SCHEMBL3983490 | 0.83 | TSHR (0.42) | NPC1RAB9AATMTDP1VCAM1 | |
| SCHEMBL6586312 | 0.83 | CA12 (0.46) | NPC1RAB9AATMTDP1VCAM1 | |
| SCHEMBL9419242 | 0.80 | TDP1 (0.41) | NPC1RAB9AATMTDP1VCAM1 | |
| SCHEMBL10515182 | 0.80 | POLB (0.49) | NPC1RAB9ATDP1KMT2APOLB | |
| SCHEMBL30033099 | 0.80 | KMT2A (0.48) | NPC1RAB9AATMTDP1VCAM1 | |
| SCHEMBL1785458 | 0.80 | MEN1 (0.48) | NPC1RAB9ATDP1VCAM1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310722-A | Synergistic composition comprising a sulfonylurea and a thiadiazolo[3,4-a]py | CIBA-GEIGY CORPORATION (US) | 1994-05-10 | — | — | US | disclosed |
| US-5229514-A | Thiourea compounds containing pyridazine ring | CIBA-GEIGY CORPORATION (US) | 1993-07-20 | — | — | US | disclosed |
| US-5135562-A | 8-thia-1,6-diazabicyclo[4.3.0]nonane herbicides | CIBA-GEIGY CORPORATION (US) | 1992-08-04 | — | — | US | disclosed |