Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.62 |
| ▸ | DRD2 | P14416 | 4/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.62 |
| ▸ | HTR2A | P28223 | 4/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.62 |
| ▸ | HRH1 | P35367 | 4/20 | 0.62 |
| ▸ | DRD3 | P35462 | 4/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.62 |
| ▸ | DRD1 | P21728 | 3/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.62 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305239 | 0.86 | KDM1A (0.60) | HTR1AADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL7468275 | 0.85 | DRD2 (0.63) | HTR1AADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL8251326 | 0.85 | DRD2 (0.53) | HTR1AADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL9419635 | 0.84 | CACNA1B (0.50) | SIGMAR1CACNA1BKDM1ACACNA1H | |
| SCHEMBL13305145 | 0.83 | KDM1A (0.64) | HTR1AADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL13305140 | 0.83 | KDM1A (0.67) | HTR1ADRD2SIGMAR1CACNA1BHTR6 | |
| SCHEMBL6102599 | 0.83 | CACNA1B (0.51) | HTR1AADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL13305143 | 0.82 | KDM1A (0.65) | HTR1AADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL13305256 | 0.82 | KDM1A (0.61) | HTR1AADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL30216960 | 0.82 | SIGMAR1 (0.46) | HTR1AADRA2ADRD2ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371081-A | Useful in potentiating the cytotoxic effect of chemotherapeutic agents | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 1994-12-06 | — | — | US | claimed |
| WO-1993003729-A1 | N-SUBSTITUTED PHENOXAZINES FOR TREATING MULTIDRUG RESISTANT CANCER CELLS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-03-04 | — | — | WO | claimed |
| US-5371081-A | Useful in potentiating the cytotoxic effect of chemotherapeutic agents | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 1994-12-06 | — | — | US | disclosed |
| WO-1993003729-A1 | N-SUBSTITUTED PHENOXAZINES FOR TREATING MULTIDRUG RESISTANT CANCER CELLS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-03-04 | — | — | WO | disclosed |