Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | P2RX4 | Q99571 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9419617 | 0.98 | ALDH1A1 (0.64) | ALDH1A1ALOX15USP2P2RX4GAA | |
| SCHEMBL6045372 | 0.89 | USP2 (0.51) | ALDH1A1ALOX15USP2P2RX4TP53 | |
| SCHEMBL6045322 | 0.87 | USP2 (0.52) | ALDH1A1ALOX15USP2P2RX4TP53 | |
| SCHEMBL9419650 | 0.87 | HTT (0.54) | ALDH1A1ALOX15USP2P2RX4GAA | |
| SCHEMBL5453524 | 0.82 | P2RX4 (0.50) | ALDH1A1ALOX15USP2P2RX4MEN1 | |
| SCHEMBL6045315 | 0.77 | MEN1 (0.53) | ALDH1A1P2RX4GAAMAPTMEN1 | |
| SCHEMBL5242431 | 0.74 | ALDH1A1 (0.44) | ALDH1A1ALOX15USP2P2RX4KDM4E | |
| SCHEMBL5241094 | 0.74 | P2RX4 (0.65) | P2RX4 | |
| SCHEMBL5451618 | 0.73 | LTA4H (0.48) | ALDH1A1GAAPKMTP53 | |
| SCHEMBL5460660 | 0.73 | TP53 (0.43) | ALDH1A1ALOX15USP2P2RX4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371081-A | Useful in potentiating the cytotoxic effect of chemotherapeutic agents | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 1994-12-06 | — | — | US | claimed |
| WO-1993003729-A1 | N-SUBSTITUTED PHENOXAZINES FOR TREATING MULTIDRUG RESISTANT CANCER CELLS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-03-04 | — | — | WO | claimed |
| US-5371081-A | Useful in potentiating the cytotoxic effect of chemotherapeutic agents | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 1994-12-06 | — | — | US | disclosed |
| WO-1993003729-A1 | N-SUBSTITUTED PHENOXAZINES FOR TREATING MULTIDRUG RESISTANT CANCER CELLS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-03-04 | — | — | WO | disclosed |