Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9422977 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL9422816 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL9422974 | 0.83 | KDM4E (0.56) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL9422764 | 0.83 | KDM4E (0.56) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9422871 | 0.82 | KDM4E (0.55) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL9422849 | 0.82 | KDM4E (0.55) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL6170644 | 0.82 | AGTR2 (0.53) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL9422890 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL9422763 | 0.81 | KDM4E (0.54) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL28517096 | 0.81 | AGTR1 (0.56) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294631-A | Substituted benzimidazoles useful as angiotension II receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0525129-A4 | SUBSTITUTED BENZIMIDAZOLES | — | 1993-03-24 | — | — | EP | disclosed |
| EP-0525129-A1 | SUBSTITUTED BENZIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-03 | — | — | EP | disclosed |
| WO-1991016313-A1 | SUBSTITUTED BENZIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-31 | — | — | WO | disclosed |