Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9423216 | 1.00 | ALDH1A1 (0.48) | ALDH1A1SIRT1LMNACYP1A2PTGS1 | |
| SCHEMBL9423154 | 0.79 | LMNA (0.43) | ALDH1A1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL9423156 | 0.79 | LMNA (0.43) | ALDH1A1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL8775237 | 0.78 | HPSE (0.43) | SIRT1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL8775300 | 0.78 | HPSE (0.43) | SIRT1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL8775462 | 0.78 | HPSE (0.43) | SIRT1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL7984845 | 0.76 | HPSE (0.44) | SIRT1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL7972796 | 0.75 | HPSE (0.40) | SIRT1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL10383431 | 0.74 | MAPT (0.53) | SIRT1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL13896928 | 0.74 | MAPT (0.53) | SIRT1LMNACYP1A2PTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5298526-A | Optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids and pharmaceutical use | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1994-03-29 | — | — | US | disclosed |
| US-5095126-A | Efficient synthesis for optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids | OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1992-03-10 | — | — | US | disclosed |